Martin-Luther-Universität Halle-Wittenberg


Prof. Dr. Alfred Blume

Telefon: 0345 5525850
Telefax: 0345 5527157

Raum 2.08.0
von-Danckelmann-Platz 4
06129 Halle

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Martin-Luther-Universität Halle-Wittenberg
Naturwissenschaftliche Fakultät II
Institut für Chemie
von-Danckelmann-Platz 4
06120 Halle (Saale)


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2005 - 2010 / 2000 - 2004 / 1990 - 1999 / 1973 - 1989


Graf, G., Drescher, S., Meister, A., Garamus, V.M., Blume, A.
Nanofiber Formation and Polymerization of Bolalipids with Diacetylene-Modified Single Alkyl Chains.
J. Phys. Chem. B, 2019, 123, 1566-1577. DOI:10.1021/acs.jpcb.8b11945   


Blume, A.
Lipids at the air-water interface.
ChemTexts 2018, 4, 3. DOI:10.1007/s40828-018-0058-z   

Drescher, S., Otto, C., Müller, S., Grünert, S., Lischka, A., Meister, A., Blume, A., Dobner, B.
The Impact of Headgroup Asymmetry and Protonation State on the Aggregation Behavior of a New Type of Glycerol Diether Bolalipids.
Langmuir 2018, 34, 4360-4373. DOI:10.1021/acs.langmuir.8b00527   

Blume, A.
In: Bioanalytics: Analytical Methods and Concepts in Biochemistry and Molecular Biology, First Edition. Friedrich Lottspeich and Joachim Engels Eds. Chpt. 4, p. 47-62, Wiley-VCH Weinheim, 2018.

Hädicke, A., Blume, A.
Interaction of Short Pentavalent Cationic Peptides with Negatively Charged DPPG Monolayers and Bilayers: Influence of Peptide Modifications on Binding.
J. Phys. Chem. B, 2018, 122, 10522-10534. DOI:10.1021/acs.jpcb.8b08667   

Lechner, B.-D., Biehl, P., Ebert, H., Werner, S., Meister, A., Hause, G., Bacia, B., Tschierske, C., Blume, A.
Controlling the Miscibility of X-shaped Bolapolyphiles with Lipids in Membranes by Varying the Chemical Structure and Size of the Polyphile Polar Headgroup.
J. Phys. Chem. B, 2018, 122, 10861-10871. DOI:10.1021/acs.jpcb.8b08582   


Drescher, S.; Garamus, V. M.; Garvey, C. J.; Meister, A.; Blume, A.,
Aggregation behaviour of a single-chain, phenylene-modified bolalipid  and its miscibility with classical phospholipids.
Beilstein J. Org.  Chem. 2017, 13, 995-1007, DOI:10.3762/bjoc.13.99    

Hädicke, A.; Blume, A.
Binding of cationic model peptides (KX)4K to  anionic lipid bilayers: Lipid headgroup size influences secondary  structure of bound peptides
Biochim. Biophys. Acta 2017, 1859 (3),  415-424. DOI:10.1016/j.bbamem.2016.12.019   

Kordts, M.; Kerth, A.; Drescher, S.; Ott, M.; Blume, A.
The cmc- value  of a bolalipid with two phosphocholine headgroups and a C 24 alkyl  chain: Unusual binding properties of fluorescence probes to bolalipid  aggregates
J. Colloid Interface Sci. 2017, 501, 294-303. DOI:10.1016/j.jcis.2017.04.077   

Reiche, K.; Hartl, J.; Blume, A.; Garidel, P.
Liquid-liquid phase  separation of a monoclonal antibody at low ionic strength: Influence of  anion charge and concentration
Biophys. Chem. 2017, 220, 7-19. DOI:0.1016/j.bpc.2016.08.003   

Hädicke, A.; Schwieger, C.; Blume, A.
Co-spreading of anionic phospholipids with peptides of the structure (KX)4K at the air-water interface: Influence of lipid headgroup structure and hydrophobicity of the peptide on monolayer behavior.
Langmuir 2017, 33, 12204-12217. DOI:10.1021/acs.langmuir.7b02255   

Meister, A.; Blume, A.
(Cryo)Transmission Electron Microscopy of Phospholipid Model Membranes Interacting with Amphiphilic and Polyphilic Molecules.
Polymers 2017, 9, 521. DOI:10.3390/polym9100521   

Shah, S. W. H. ; Schwieger, C.; Li, Z.; Kressler, J.; Blume, A.
Effect of Perfluoroalkyl Endgroups on the Interactions of Tri-block Copolymers with Monofluorinated F-DPPC Monolayers.
Polymers 2017, 9, 555. DOI:10.3390/polym9110555   

Markowski, T.; Müller, S.; Dobner, B.; Meister, A.; Blume, A.; Drescher, S.
An Asymmetrical Glycerol Diether Bolalipid with Protonable Phosphodimethylethanolamine Headgroup: The Impact of pH on Aggregation Behavior and Miscibility with DPPC.
Polymers 2017, 9, 573. DOI:10.3390/polym9110573   

Schwieger, C.; Meister, A.; Daum, S.; Blume, A.; Bacia, K.
Binding of the GTPase Sar1 to a Lipid Membrane Monolayer: Insertion and Orientation studied by Infrared-Reflection-Absorption Spectroscopy.
Polymers 2017, 9, 612. DOI:10.3390/polym9110612   


Blume, A.
Temperature induced and isothermal phase transitions of pure and mixed lipid bilayer membranes studied by DSC and ITC.
In Biocalorimetry: Foundations and Contemporary Approaches, Bastos, M., Ed.; CRC Press: Boca Raton, VA., USA, 2016, pp 103-136.

Achilles, A.; Barenwald, R.; Lechner, B. D.; Werner, S.; Ebert, H.; Tschierske, C.; Blume, A.; Bacia, K.; Saalwachter, K.
Self-Assembly of X-Shaped Bolapolyphiles in Lipid Membranes: Solid-State NMR Investigations.
Langmuir 2016, 32, 673-82. DOI:10.1021/acs.langmuir.5b03712   

Hadicke, A.; Blume, A.
Binding of the Cationic Peptide (KL)4K to Lipid Monolayers at the Air-Water Interface: Effect of Lipid Headgroup Charge, Acyl Chain Length, and Acyl Chain Saturation.
J. Phys. Chem. B
2016, 120, 3880-7. DOI:10.1021/acs.jpcb.6b01558   

Hadicke, A.; Blume, A.
Binding of cationic peptides (KX)K to DPPG bilayers. Increasing the hydrophobicity of the uncharged amino acid X drives formation of membrane bound beta-sheets: A DSC and FT-IR study.
Biochim. Biophys. Acta 2016, 1858, 1196-1206. DOI:10.1016/j.bbamem.2016.02.021   

Schwieger, C.; Blaffert, J.; Li, Z.; Kressler, J.; Blume, A.
Perfluorinated Moieties Increase the Interaction of Amphiphilic Block Copolymers with Lipid Monolayers.
Langmuir 2016, 32 (32), 8102-8115. DOI:10.1021/acs.langmuir.6b01574   


Finger, S.; Kerth, A. M.; Dathe, M.; Blume, A.
The efficacy of trivalent cyclic hexapeptides to induce lipid clustering in PG/PE membranes correlates with their antimicrobial activity.
Biochimica et Biophysica Acta 2015, 1848, 2998-3006. DOI:10.1016/j.bbamem.2015.09.012   

Hadicke, A.; Blume, A.
Binding of Short Cationic Peptides (KX)4K to Negatively Charged DPPG Monolayers: Competition between Electrostatic and Hydrophobic Interactions.
Langmuir 2015, 31, 12203-14. DOI:10.1021/acs.langmuir.5b02882   

Lechner, B. D.; Roper, S.; Messerschmidt, J.; Blume, A.; Magerle, R.
Monitoring Demineralization and Subsequent Remineralization of Human Teeth at the Dentin-Enamel Junction with Atomic Force Microscopy.
ACS Appl. Mater. Interfaces 2015, 7, 18937-43. DOI:10.1021/acsami.5b04790   

Markowski, T.; Drescher, S.; Forster, G.; Lechner, B. D.; Meister, A.; Blume, A.; Dobner, B.
Highly Asymmetrical Glycerol Diether Bolalipids: Synthesis and Temperature-Dependent Aggregation Behavior.
Langmuir 2015, 31, 10683-92. DOI:10.1021/acs.langmuir.5b02951   

Scholtysek, P.; Shah, S. W. H.; Müller, S.; Schöps, R.; Frey, H.; Blume, A.; Kressler, J.
Unusual triskelion patterns and dye-labelled GUVs: Consequences of the interaction of cholesterol-containing linear-hyperbranched block copolymers with phospholipids.
Soft Matter 11, 2015, 6106-6117. DOI:10.1039/c5sm01017a   

Garidel, P.; Blume, A.; Wagner, M.
Prediction of colloidal stability of high concentration protein formulations.
Pharmaceutical Development and Technology Online, 2015, 20  (3), 367-74 DOI:10.3109/10837450.2013.871032   

Hädicke, A.; Blume, A.
Interactions of Pluronic Block Copolymers with Lipid Vesicles Depend on Lipid Phase and Pluronic Aggregation State.
Coll. Polymer Sci. 293, 2015, 267–276. DOI:10.1007/s00396-014-3414-6   

Lechner, B.-D.; Ebert, H.; Prehm, M.; Werner, S.; Meister, A.; Hause, G.; Beerlink, A.; Saalwächter, K.; Bacia, K.; Tschierske, C.; Blume, A.
Temperature dependent in-plane structure formation of an X-shaped bolapolyphile within lipid bilayers
Langmuir 31, 2015, 2839-2850. DOI:10.1021/la504903d   

Werner, S.; Ebert, H.; Achilles, A.; Poppe, S.; Lechner, B.-D.; Blume, A.; Saalwächter, K.; Tschierske, C.; Bacia, K.
Dendritic Domains with Hexagonal Symmetry Formed by X-Shaped Bolapolyphiles in Lipid Membranes
Chemistry Eur. J. 2015, 21, 24, 8840–8850  DOI:10.1002/chem.201405994   

Lechner, B.-D.; Röper, S.; Messerschmidt, J.; Blume, A.; Magerle, R.
Monitoring demineralization and subsequent remineralization of human teeth at the dentin-enamel junction with atomic force microscopy.
ACS Appl. Mater. Interfaces 7, 2015, 18937−18943. DOI:10.1021/acsami.5b04790   

Finger, S.; Dathe, M.; Blume, A.
The efficacy of trivalent cyclic hexapeptides to induce lipid clustering in PG/PE membranes correlates with their antimicrobial activity.
Biochim. Biophys. Acta. 1848, 2015, 2998-3006. DOI:10.1016/j.bbamem.2015.09.012   

Markowski, T.; Drescher, S.; Förster, G.; Lechner, B.-D.; Meister, A.; Blume, A.; Dobner, B.
Highly asymmetrical glycerol diether bolalipids: synthesis and temperature-dependent aggregation behavior.
Langmuir 31, 2015, 10683−10692. DOI:10.1021/acs.langmuir.5b02951   


Blume, A.; Drescher, S.; Graf, G.; Köhler, K.; Meister, A.
Mixing behaviour of single-chain bolaphospholipids and their miscibility with phospholipids or classical amphiphiles.
Adv. Coll. Interf. Sci. Online 208, 2014, 264-278. DOI:10.1016/j.cis.2014.01.002   

Wölk, C.; Pawlowska, D.; Drescher, S.; Auerswald, A.; Meister, A.; Blume, A.; Brezesinski, G.; Langner, A.; Dobner, B.
New Micellar Transfection Agents.
Langmuir 30, 2014, 4905−4915. DOI:10.1021/la404860w   

Markowski, T.; Drescher, S.; Meister, A.; Blume, A.; Dobner , B.
Synthesis and physicochemical characterisation of diglycerol tetraether model lipids containing racemic methyl branches at selected positions.
Org. Biomolec. Chem. 12, 2014, 3649-3662. DOI:10.1039/C4OB00048J   

Finger, S.; Schwieger, C.; Blume, A. (2014)
Interactions of oligoamines with negatively charged lipid bilayers and monolayers
Biological Chemistry 395, 769-778, DOI:10.1515/hsz-2014-0126   

Christian Schwieger, C.; Achilles, A.; Scholz, S.; Rüger, J.; Bacia, K.; Saalwaechter, K.; Blume, A.; Kressler, J.
Binding of Triphilic Block Copolymers to Lipid Model Membranes: The Role of Perfluorinated Moieties
Soft Matter 10, 2014, 6147-6160, DOI:10.1039/c4sm00830h   

Drescher, S.; Lechner, B.-D.; Garamus, V. M.; Almásy, L.; Meister, A.; Blume, A.
The headgroup (a)symmetry strongly determines the aggregation behavior of single-chain phenylene-modified bolalipids and their miscibility with classical phospholipids.
Langmuir 30, 2014, 9273-9284, DOI:10.1021/la501160s   

Meister, A.; Finger, S.; Hause, G.; Blume, A.
Morphological changes of bacterial model membrane aggregates
Eur. J. Lipid Sci. Tech. 116, 2014, 1228-1233, DOI:10.1002/ejlt.201300388   

Drescher, S.; Meister, A.; Garamus, V. M.; Hause, G.; Garvey, C.; Dobner, B.; Blume, A.
Phenylene bolaamphiphiles: Influence of the substitution pattern on the aggregation behavior and the miscibility with classical phospholipids
Eur. J. Lipid Sci. Tech. 116, 2014, 1205-1216, DOI:10.1002/ejlt.201300387   


Graf, G.; Drescher, S.; Meister, A.; Haramus, V. M.; Dobner, B.; Blume, A.
Bolaamphiphile fiber aggregation can be modulated by the introduction of sulfur atoms into the alkyl chains.
J. Coll. Interf. Sci. 393, 2013, 143-150, DOI:10.1016/j.jcis.2012.10.017   

Blume, A.; Drescher, S.; Meister, A.; Graf, G.; Dobner, B.
Tuning the Aggregation Behavior of Single-Chain Bolaphospholipids in Aqueous Suspension: From Nanoparticles to Nanofibers to Lamellar Phases
Faraday Discussions 161, 2013, 193-213, DOI:10.1039/C2FD20102J   

Wagner, M.; Reiche, K.; Blume, A.; Garidel, P.
Viscosity Measurements of Antibody Solutions by Photon Correlation Spectroscopy: An Indirect Approach. Limitations and Applicability for High-Concentration Liquid Protein Formulations.
Pharmaceutical Development and Technology 18, 2013, 963-970. DOI:10.3109/10837450.2011.649851.   

Blume, A. and Kerth, A.
Peptide and Protein Binding to Lipid Monolayers Studied by FT-IRRAS.
Biochim. Biophys. Acta 1828, 2013, 2294-2305.

Arouri, A.; Dathe, M.; Blume, A.
The helical propensity of KLA amphipathic peptides enhances their binding to lipid membranes: An ITC study.
Biophys. Chem. 180-181, 2013, 10-20.

Hädicke, A.; Blume, A.
Interactions of Pluronic block copolymers with lipid monolayers studied by epi-fluorescence microscopy and by adsorption experiments.
J. Coll. Interf. Sci., 407, 2013, 327-338.

Khanal, B. P.; Grimm, E.; Finger, F.; Blume, A.; Knoche, M.
Intracuticular wax fixes and restricts strain of leaf and fruit cuticles.
New Phytologist 200, 2013, 134-143. DOI:10.1111/nph.12355   

Wölk, C.; Drescher, S.; Meister, A.; Blume, A.; Langner, A.; Dobner, B.
General Synthesis and Physicochemical Characterisation of a Series of Novel Peptide-Mimic Lysine-Based Amino-Functionalised Lipids.
Chemistry - A European Journal 19, 2013, 12824 – 12838. DOI:10.1002/chem.201204529   

Graf, G., Drescher, S., Meister, A., Markowski, T.; Haramus, V. M.; Dobner, B.; Blume, A.
Aggregation Behavior of Asymmetrical Single-Chain Bolaamphiphiles in Aqueous Suspension.
Soft Matter 9, 2013, 9562–9571. DOI:10.1039/c3sm51778k   

2011 - 2012

Blume, A.; Kerth, A.
Infrarot-Reflexions-Absorptions-Spektroskopie (IRRAS).
GIT-Labor-Fachzeitschrift 2012, 56, 861-863.

Scholtysek, P.; Li, Z.; Kressler, J.; Blume, A.
Interactions of DPPC with semitelechelic poly(glycerol methacrylate)s with perfluoroalkyl endgroups.
Langmuir, 2012, 28, 15651−15662, DOI:10.1021/la3028226.   

Blume, A.; Kressler, J.
Auf der Spur von Multitalenten.
DFG Magazin Forschung, 2012, Heft 3/2012, 26-29

Wagner, M.; Reiche, K.; Blume, A.; Garidel, P.
The Electrokinetic Potential of Therapeutic Proteins and its Modulation: Impact on Protein Stability.
Colloids Surf. A, 2012, 415, 421-430, DOI:10.1016/j.colsurfa.2012.09.024   

Drescher, S.; Sonnenberger, S.; Meister, A.; Althaus, S.; Dobner, B.; Blume, A.
Synthesis of symmetrical, single-chain, phenylene/
biphenylene-modified bolaamphiphiles,
Monatshefte Chemie- Chemical Monthly, 2012, 143, 1533-1543.

Olubummo, A.; Schulz, M.; Lechner, B.-D.; Scholtysek, P.; Bacia, K.; Blume, A.; Kressler, J.; Binder, W.
Controlling the Localization of Polymer-Functionalized Nanoparticles in Mixed Lipid/Polymer Membranes
ACS-Nano 6, 2012, 8713–8727. DOI:10.1021/nn3023602   

Schwieger, C.; Chen, B.; Tschierske, C.; Kressler, J.; Blume, A.
Organization of T-Shaped Facial Amphiphiles at the Air/Water Interface Studied by Infrared Reflection Absorption Spectroscopy
J. Phys. Chem. B, 2012, 116, 12245–12256, DOI:10.1021/jp306612k   

Meister, A.; Blume, A.
Single-Chain Bolaphospholipids: Temperature-Dependent Self-Assembly and Mixing Behavior with Phospholipids
Advances in Planar Lipid Bilayers 16, 2012, 93–128.

Drescher, S.; Becker, S.; Dobner, B. and Blume, A.
Bis-Sonogashira Cross-Coupling: An Expeditious Approach towards Long-Chain, Phenylene-Modified 1,w-Diols.
RSC Advances 2, 2012, 4052-4054.

Drescher, S.; Hempel, G.; Binder, W. H.; Dobner, B.; Blume, A.; Meister, A.
Functionalization of Bolalipid Nanofibers by Silicification and Subsequent One-Dimensional Fixation of Gold Nanoparticles
Langmuir, 2012,  28, 11615−11624, DOI:la-2012-02348t.R1   

Scholtysek, P., Achilles, A., Drescher, s., Hoffmann, C., Lechner, B., Meister, A, Reuter, S., Saalwächter, K., Edwards, K., Blume, A. (2012)
A T-shaped amphiphilic molecule forms closed vesicles in water and bicelles in mixtures with the phospholipid dipalmitoyl-phosphatidylcholine.
J. Phys. Chem. B. 116, 4871-4878, DOI:10.1021/jp207996r   

Heerklotz, H. and Blume, A.
Detergent Interactions with Lipid Bilayers and Membrane Proteins.
In: Edward H. Egelman, editor: Comprehensive Biophysics, Vol 5, Membranes, Lukas Tamm. Oxford: Academic Press, 2012, pp. 63-91.

Wagner, M., Reiche, K., Blume, A., Garidel, P. (2012)
Viscosity Measurements of Antibody Solutions by Photon Correlation Spectroscopy: An Indirect Approach. Limitations and Applicability for High-Concentration Liquid Protein Formulations.
Pharmaceutical Development and Technology. DOI:10.3109/10837450.2011.649851.    published online.

Blume, A.
In: Bioanalytik, 3. Auflage (F. Lottspeich, Engels, Hrsg.) Kapitel 5 Mikrokalorimetrie, S. 59-75, Springer-Verlag, Berlin Heidelberg, 2012.

Kerth, A., Brehmer, T., Meister, A., Hanner, P., Jakob, M., Klösgen, R.-B., Blume, A. (2012)
Interaction of TAT Substrates with Thylakoid Lipids at the Air-Water Interface.
ChemBioChem 13, 231-239.

Brehmer, T., Kerth, A., Graubner, W., Malesivic, M., Huo, B., Brüser, T., Blume, A. (2012)
Negatively charged phospholipids trigger the interaction of a bacterial Tat substrate precursor protein with lipid monolayers.
Langmuir 28, 3534-3541

Kerth, A., Blume, A. (2012)
IRRA-Spektroskopie: Wechselwirkung von Proteinen mit Lipidmonoschichten,
Biospektrum 17, 156-158

Hörnke, M., Schwieger, C., Kerth, A., Blume, A. (2012)
Binding of cationic pentapeptides with modified side chain lengths to negatively charged lipid membranes: Complex interplay of electrostatic and hydrophobic interactions.
Biochim. Biophys. Acta. 1818, 1663–1672 doi:10.1016/j.bbamem.2012.03.001   

Graf, G., Drescher, S. Meister, A., Dobner, B., Blume, A. (2011)
Self-Assembled Bolaamphiphile Fibers have Intermediate Properties between Crystalline Nanofibers and Wormlike Micelles: Formation of Viscoelastic Hydrogels Switchable by Changes in pH and Salinity.
J.Phys.Chem. B 115, 10478–10487.

Markowski, T., Meister, A., Hause, G., Drescher, S., Blume, A. and Dobner, B. (2011)
Synthesis of Optical Pure Diglyceroltetraether Model Lipids with Non-Natural Branching Pattern.
Eur. J. Org. Chem. 2011; 5894-5904.

Schulz, M., Glatte, D., Meister, A., Scholtysek, P., Kerth, A., Blume, A., Bacia, K. and Binder, W. (2011)
Hybrid lipid/polymer giant unilamellar vesicles: Effects of incorporated biocompatible PIB-PEO block copolymers on vesicle properties.
Soft Matter 7,           8100-8110.

Garidel, P., Johann, C., Blume, A. (2011)
A Calorimetric Study of Nonideal Mixing and Phase Separation in Phosphatidic Acid-Phosphatidylethanolamine Mixtures as a Function of pH and Chain Length. Eur. Biophys. J. 40, 891-905.

Arouri, A., Kerth, A., Dathe, M., Blume, A. (2011)
The binding of an amphipathic peptide to a lipid monolayer at the air/water interface is modulated by the lipid headgroup structure. Langmuir 27, 2881-2888.

Bastrop, M., Meister, A., Metz, H., Drescher, S., Dobner, B., Mäder, K., Blume A. (2011)
Water dynamics in bolaamphiphile hydrogels investigated by 1H-NMR relaxometry and diffusometry. J. Phys. Chem. B, 115, 14–22.

Arouri, A., Kiessling, V., Tamm, L., Dathe, M., Blume, A. (2011)
Morphological changes induced by the action of antimicrobial peptides on supported lipid bilayers. J. Phys. Chem. B, 115, 158–167.

2005 - 2010

Li, H.; Pfefferkorn, D.; Kerth, A.; Blume, A.; Binder, W. H.; Kressler, J.. (2010)
Silica nanoparticle formation on Langmuir films of amphiphiles.
Polymer Preprints (American Chemical Society, Division of Polymer Chemistry) 51(1), 214-215.

Kyeremateng, S. O., Schwieger, C.,  Blume, A., Kressler, J. (2010)
Triphilic Block Copolymers: Synthesis, Aggregation Behavior and Interactions with Phospholipid Membranes.
In: ACS Symposium Series "Contemporary Science of Polymeric Materials". Ljiljana Korugic-Karasz (Ed.) Vol 1061, Chapter 5, pp 65-84.

Heuert, U., Krumova, M., Hempel, G., Schiewek, M., Blume, A. (2010)
NMR probe for pressure-jump experiments up to 250 bar and 3 ms jump time. Rev. Sci. Instr. 8, 105102.

Welker, S. Rudolph, B., Frenzel, E., Hagn, F., Liebisch, G., Schmitz, G., Scheuring, J., Kerth, A., Blume, A., Weinkauf, S., Haslbeck, M., Kessler, H., and Buchner, J. (2010)
Hsp12 Is an Intrinsically Unstructured Stress Protein which Folds upon Membrane Association and Modulates Membrane Function. Molecular Cell 39, 507–520.

Fricker, G., Kromp, T., Wendel, A., Blume, A., Zirkel, J., Rebmann, H., Setzer, C., Martin, F., Quinkert, R.O., Taylor, L., Massing, U., Müller-Goymann, C. (2010)
Phospholipids and lipid-based formulations in oral drug delivery. Pharmaceutical Research 27, 1469-1486

Amado, E., Blume, A. and Kressler, J. (2010)
Adsorbed and Spread Films of Amphiphilic Triblock Copolymers Based on Poly(2,3-dihydroxypropyl methacrylate) and Poly(propylene oxide) at the Air-Water Interface Langmuir 26, 5507-5519

Schiewek, M. and Blume, A. (2010)
Phase Transition Kinetics of Lipid Bilayer Membranes Studied by Time-Resolved Pressure Perturbation Calorimetry. Eur. Biophys. J. 39, 815–824.

Meister, A., Drescher, S., Karlsson, G., Hause, G., Baumeister, U., Hempel, G. Garamus, V. M., Dobner, B., Blume A. (2010)
Formation of Square Lamellae by Self-Assembly of Long-Chain Bolaphospholipids in Water. Soft Matter 6, 1317–1324.

Knauf, K., Meister, A., Kerth, A. and Blume, A.(2010)
Interaction of alkyltrimethylammonium bromides with DMPC-d54 and DMPG-d54 monolayers studied by infrared reflection absorption spectroscopy (IRRAS). J. Coll. Interface Sci. 342, 243–252.

Kerth, A., Garidel, P., Howe, J., Alexander, C., Mach, J.-P., Waelli, T., Blume, A., Rietschel, E. Th. and Brandenburg, K. (2009)
An infrared reflection-absorption spectroscopic (IRRAS) study of the interaction of lipid A and lipopolysaccharide Re with endotoxin-binding proteins. Med. Chem. 5, 535-542.

Erbe, A. Kerth, A., Dathe, M. and Blume, A. (2009)
Interactions of KLA amphipathic model peptides with lipid monolayers. An infrared reflection absorption spectroscopy study. ChemBioChem 10, 2884 – 2892.

Meister, A. Blume, A. (2009)
Frust bei der Packung. Nachrichten aus der Chemie 57, 971-976.

Schwieger, C. Blume, A. (2009)
Interaction of Poly(L-arginine) with Negatively Charged DPPG Membranes: Calorimetric and Monolayer Studies. Biomacromolecules 10, 2152-2161.

Reuter, M., Schwieger, C., Meister, A. Karlsson, G. and Blume, A. (2009)
Poly-L-lysines and poly-L-arginines induce leakage of negatively charged phospholipid vesicles and translocate through the lipid bilayer upon electrostatic binding on the membrane. Biophys. Chem. 144, 27-37.

Garidel, P., Hoffmann, C., Blume, A. (2009)
A Thermodynamic Analysis of the Binding Interaction Between Polysorbate 20 and 80 with Human Serum Albumins and Immunoglobulins: A Contribution to Understand Colloidal Protein Stabilisation. Biophys. Chem. 143, 70-78.

Mackenzie, C. D., Smith, B. O., Meister, A., Blume, A., Zhao, X., Lu, J. R., Kennedy, M. W., and Cooper, A. (2009)
Ranaspumin-2: the structure and function of a surfactant protein from the foam nests of a tropical frog. Biophys. J. 96, 4984–4992.

Amado, E., Blume, A. and Kressler, J. (2009)
Novel non-ionic block copolymers tailored for interactions with phospholipids. React. Funct. Polym. 69, 450-456.

Hoffmann, C., Blume, A., Miller, I., Garidel, P. (2009)
Insights into Protein-Polysorbate Interactions Analysed by Means of Isothermal Titration and Differential Scanning Calorimetry. Eur. Biophys. J. 38, 567-568.

Arouri, A., Dathe, M., Blume, A. (2009)
Peptide induced demixing in PG/PE lipid mixtures: a mechanism for the specificity of antimicrobial peptides towards bacterial membranes? Biochim. Biophys. Acta 1788, 650-659.

Bastrop, M., Meister, A., Metz, H., Drescher, S., Dobner, B., Mäder, K., Blume, A. (2009)
The motional dynamics in bolaamphiphilic nanofibers and micellar aggregates: An ESR spin probe study. J. Phys. Chem. B 113, 574-582.

Amado, E., Kerth, A., Blume, A., Kressler, J. (2009)
Phospholipid crystalline clusters induced by adsorption of novel amphiphilic triblock copolymers to monolayers. Soft Matter 5, 669-675.

Schiewek, M., Blume, A. (2009)
A Pressure Jump Relaxation Study of Lipid Membrane Phase Transitions Using Time-Resolved FTIR Spectroscopy. Eur. Biophys. J. 38, 219-228.

Kuppe, K., Blume, A., Kerth, A., Ulbrich-Hofmann, R. (2008)
Calcium induced membrane microdomains trigger plant phospholipase D activity. ChemBioChem 9, 2853-2859.

Amado, E., Kerth, A., Blume, A., Kressler, J. (2008)
Infrared reflection absorption spectroscopy coupled with Brewster angle microscopy for studying interactions of amphiphilic triblock copolymers with phospholipid monolayers. Langmuir 24, 10041-10053.

Kyeremateng, S.O., Amado, E., Blume, A., Kressler, J. (2008)
Synthesis of ABC and CBABC Triphilic Block Copolymers by ATRP Combined with 'Click' Chemistry. Macromolecular Rapid Communications 29, 1140-1146.

Drescher, S., Meister, A., Graf, G., Blume, A., Hause G., Dobner, B. (2008)
Novel single-chain bolaphospholipids with sulphur- and oxygen-containing chain and headgroup structures. Chem. Eur. J. 14, 6796-6804.

Meister, A., Drescher, S., Garamus, V.M., Karlsson, G., Dobner, B., Blume, A. (2008)
Temperature-dependent self-assembly and mixing behavior of symmetrical single-chain bolaamphiphiles. Langmuir 24, 6238-6246

Ropers M.H., Meister A., Blume A., Ralet M.C. (2008)
Pectin/Lipid assembly at the air-water interface - Effect of the pectin charge distribution. Biomacromolecules 9, 1306-1312.

Meister, A., Drescher, S., Mey, I., Wahab, M., Graf, G., Hause, G., Mögel, H.-J., Janshoff, J., Dobner, B., Blume, A. (2008)
Helical Nanofibers of Self-Assembled Bipolar Phospholipids as Template for Au Nanoparticles. J. Phys. Chem B 112; 4506-4511.

Garidel, P., Hildebrand, A., Blume, A. (2007)
Membranolytic activity of bile salts: Influence of biological membrane composition. Molecules 12, 2292-2326.

Lopes, D.H.J., Meister, A., Gohlke, A.,Hauser, A.,Blume, A. Winter, R. (2007)
Mechanism of IAPP Aggregation at Lipid Interfaces Studied by Infrared Reflection Absorption Spectroscopy (IRRAS), Biophys. J. 93, 3132-3141.

Meister, A., Köhler, K., Drescher, S., Dobner, B., Karlsson, G., Edwards, K., Hause, G., Blume, A. (2007)
Mixing Behavior of a Symmetrical Single-Chain Bolaamphiphile with Phospholipids. Soft Matter 3, 1025-1031.

Meister, A., Blume, A. (2007)
Self-assembly of bipolar amphiphiles. Curr. Opin. Coll. Interf. Sci. 12; 138-147.

Arouri, A., Garidel, P., Kliche, W., Blume, A. (2007) IgG1 interaction with peptide mimotopes: a calorimetric study using isothermal titration calorimetry (ITC). Eur. Biophys. J. 36, 647-660.

Meister, A., Bastrop, M., Koschoreck, S., Garamus, V.M., Sinemus, T., Hempel, G., Drescher, S., Dobner, B., Richtering, W., Huber, K., Blume, A. (2007)
Structure-Properties Relationships in Stimuli-Responsive Bolaform Hydrogels. Langmuir 23, 7715-7723.

Schiewek, M., Krumova, M., Hempel, G., Blume, A. (2007)
An Apparatus for Pressure Jump Experiments up to 100 bar and millisecond resolution using IR-Spectroscopy as a detection system. Rev. Sci. Instr. 78, 045101.

Drescher, S., Meister, A., Blume, A., Karlsson, G., Almgren, M., Dobner, B. (2007)
General Synthesis and Phase Behaviour of a Series of Single-chained 1,w-Bis(phosphocholines). Chem. Europ. J 13, 5300-5307.

Meister, A. Weygand, M.J., Brezesinski, G., Kerth, A., Köhler, K., Drescher, S., Dobner, B., Blume, A. (2007)
Evidence for a Reverse U-shaped Conformation of Single-Chain Bolaamphiphiles at the Air-Water Interface. Langmuir 23, 6063-69

Schwieger, C., Blume, A. (2007)
Interaction of poly(L-lysines) with negatively charged membranes: an FT-IR and DSC study. Eur. Biophys. J. 36,437-450

Förster, G., Schwieger, C., Faber, F., Weber, T., Blume, A. (2007)
Influence of Poly-L-lysine on the Structure of Dipalmitoylglycerophosphoglycerol/Water Dispersions Studied by X-Ray-Scattering. Eur. Biophys. J. 36, 425-435.

Keller, S., Böthe, M., Bienert, M., Dathe, M., Blume, A. (2007)
A Simple Fluorescence-Spectroscopic Membrane Translocation Assay. ChemBioChem 8, 546-552.

Amado, E., Augsten, C., Mäder, K., Blume, A., Kressler, J. (2006)
Amphiphilic Water Soluble Triblock Copolymers Based on Poly(2,3-dihydroxypropyl methacrylate) and Poly(propylene oxide): Synthesis by Atom Transfer Radical Polymerization and Micellization in Aqueous Solutions. Macromolecules 39, 9486-9496.

Dyck, M., Kerth, A., Blume, A., Lösche, M. (2006)
Interaction of the neurotransmitter, neuropeptide Y (NPY), with phospholipid membranes: Infrared spectroscopic characterization at the air/water interface. J. Phys. Chem. B 110, 22152-22159.

Meister, A., Nicolini, C., Waldmann, H., Kuhlmann K., Kerth, A., Winter, R., and Blume, A. (2006)
Insertion of Lipidated Ras Proteins into Ternary Lipid Mixtures Studied by Infrared Reflection Absorption Spectroscopy. Biophys. J. 91, 1388-1401.

Keller, S., Heerklotz, H., Jahnke, N., Blume, A. (2006) Thermodynamics of Lipid Membrane Solubilization by Sodium Dodecyl Sulfate. Biophys. J. 90, 4509-4521.

Beyer, K., Leine, D., Blume, A. (2006)
The demicellization of alkyltrimethylammonium bromides in 0.1 M sodium chloride solution studied by isothermal titration calorimetry. Coll. Surf. B 49, 31-39.

Köhler, K., Meister, A., Dobner, B., Heiser, U.F., Ziethe, F., Blume, A. (2006)
Temperature dependent Behavior of Symmetric Long-Chain Bolaamphiphiles at the Air-Water Interface. Langmuir 22, 2668-2675.

Keller, S., Heerklotz, H., Blume, A. (2006)
Monitoring Membrane Translocation by Isothermal Titration Calorimetry. J. Am. Chem. Soc. 128, 1279-1286.

Köhler, K., Meister, A., Förster, G., Dobner, B., Drescher, S., Ziethe, F., Richter, W., Steiniger, F., Drechsler, M., Hause, G., Blume, A. (2006)
Conformational and Thermal Behavior of a pH-Sensitive Bolaform Hydrogelator. Soft Matter 2, 77-86.

Augsten, M., Pusch, R., C. Biskup, Rennert, K., Wittig, U., Beyer, K., Blume, A., Wetzker, R., Friedrich, K., Rubio, I. (2006)
Live-cell imaging of endogenous Ras-GTP illustrates predominant Ras activation at the plasma membrane. EMBO-Reports 7, 46-51.

Garidel, P., Johann, C., Blume, A. (2005)
The calculation of heat capacity curves and phase diagrams based on regular solution theory. J. Therm. Anal. Calorimetry 82, 447-455.

Garidel, P., Blume, A. (2005)
1,2-Dimyristoyl-sn-glycero-3-phosphoglycerol (DMPG) Monolayers: Influence of Temperature, pH, Ionic Strength and Binding of Alkaline Earth Cations. Chem. Phys. Lipids 138, 50-59.

Maltseva, E., Brezesinski, G., Moehwald, H., Kerth, A., Blume, A. (2005)
Adsorption of Amyloid b (1-40) peptide to differently charged phospholipid monolayers. ChemBioChem 6, 1817-1824.

Meister, A., Kerth, A., Blume, A. (2005)
Adsorption Kinetics of n-Nonyl-b-d-glucopyranoside at the Air-Water Interface Studied by Infrared Reflection Absorption Spectroscopy. J. Phys. Chem. B 109, 6239-6246.

Hussain, H., Busse, K., Kerth, A., Blume, A., Melik-Nubarov, N.S., Kressler, J. (2005)
Interaction of poly(ethylene oxide) and poly(perfluorohexylethyl methacrylate) containing block copolymers with biological systems. ACS Symp. Ser. 916, 92-105.

Hübner, W., Blume, A., Pushnjakova, R., Dekhtyar, Y., Hein, H.-J. (2005)
The Influence of X-ray Radiation on the Mineral/Organic Matrix Interaction of Bone Tissue: An FT-IR Microscopic Investigation. Internatl. J. Artificial Organs. 28, 66-73.

(nach oben)

2000 - 2004

Hussain, H., Kerth, A.,. Busse, K., Blume, A., Kressler, J. (2004)
Block copolymers in contact with lipid monolayer. Polym. Prepr. (Am. Chem. Soc., Polym. Mat. Eng. Sci.), 90(1), 563-564.

Meister, A., Kerth, A., Blume, A. (2004)
The interaction of n-nonyl-b-d-glucopyranoside and sodium dodecyl sulfate with DMPC and DMPG monolayers studied by Infrared Reflection Absorption Spectroscopy. Phys. Chem. Chem. Phys. 6, 5543-5550.

Köhler, K., Förster, G., Hauser, A., Dobner, B., Heiser, U.F., Ziethe, F., Richter , W., Steiniger, F., Drechsler, M., Blume, A. (2004)
Temperature Dependent Characterization of a Symmetric Long-chain Bolaamphiphile with Phosphocholine Headgroups in Water: From Hydrogel to Nanoparticles. J. Amer. Chem. Soc. 126, 16804-16813.

Blume, A. (2004)
Assoziationskolloide oder Der Widerstreit der Gefühle bei amphiphilen Molekülen. HighChem hautnah, Deutsche Bunsengesellschaft für Physikalische Chemie, 16-18.

Garidel, P., Hauser, A., Förster , G., Blume, A., Rapp, G. (2004)
Insights into Ceramide 3A Molecular Arrangement. Hasylab Annual Report 2004, 801-802.

Garidel, P., Hildebrand, A., Blume, A. (2004)
Understanding the Self-Organisation of Association Colloids. MicroCal Application Note, 1-9.

Hildebrand, A., Beyer, K., Neubert, R., Garidel, P., Blume, A. (2004)
Solubilisation of negatively charged DPPC/DPPG liposomes by bile salts. J. Coll. Interf. Sci. 279, 559-571.

Hussain, H., Kerth, A., Blume, A., Kressler, J. (2004)
Amphiphilic block copolymers of poly(ethylene oxide) and poly(perfluorohexylethyl-methacrylate) on water surface and their penetration into lipid monolayer. J. Phys. Chem. B 108, 9962-9969.

Meister, A., Kerth, A., Blume, A. (2004)
Interaction of Sodium Dodecyl Sulfate with DMPC Monolayers studied by Infrared Reflection Absorption Spectroscopy –a new Method for the Determination of Partition Coefficients. J. Phys. Chem. B, 108, 8371-8378.

Blume, A., Winter, R. (2004)
Biomolekulare Grenzflächen. Bunsenmagazin 2/2004, 27-35.

Kerth, A., Erbe, A., Dathe, M., Blume, A. (2004)
Infrared Reflection Absorption Spectroscopy of Amphipathic Model Peptides at the Air/Water Interface. Biophys J. 86. 3750-3758.

Blume, A. (2004)
Bioelectrochemistry of Membranes (D. Walz, J. Teissié, G. Milazzo, Eds.) Chapter 3. Lipids. Birkhäuser-Verlag, Basel, pp. 61-152.

Meister, A., Blume, A. (2004)
Solubilization of DMPC and DMPG Vesicles with Sodium Dodecyl Sulfate and Octylglucoside studied by FT-IR Spectroscopy. Phys. Chem. Chem. Phys. 6, 1551-1556.

Hildebrand, A., Garidel, P., Neubert, R., Blume, A. (2004)
Thermodynamics of Demicellisation of Mixed Micelles Composed of Sodium Oleate and Bile Salts. Langmuir 20, 320-328.

Köhler, K., Förster, G., Hauser, A., Dobner, B., Heiser, U.F., Ziethe, F., Richter , W., Steiniger, F., Drechsler, M., Blume, A. (2004)
Self Assembly Stress in a Bipolar Phosphocholine-Water System: The Formation of Nanofibers and Hydrogels. Angew. Chem. 116, 247-249; Angew. Chem. Int. Ed. 43, 245-247.

Blume, A. (2003)
Self-Assembly (B.H. Robinson, Ed.) Thermodynamics of concentration- and temperature-induced monomer-micelle and micelle-vesicle transitions. pp. 389-409. IOS Press, Amsterdam.

Garidel, P., Hauser, A., Förster, G., Blume, A., Rapp, G. (2003)
Aggregation Behavior of Ceramide Class 3 Lipids. Hasylab Annual Report 2003, 1009-1010.

Scheuermann, T., Blume, A., Schulz, B., Wahle, E., Rudolph, R., Schwarz, E. (2003)
Trinucleotide expansions leading to an extended poly-L-alanine segment in the poly (A) binding protein PABPN1 cause fibril formation. Protein Sci., 12, 2685-2692.

Blume, A. (2003)
Membranen, Mizellen, Nanofasern, Nanopartikel oder: Der Widerstreit der Gefühle bei amphiphilen Molekülen. Wissenschaftsjournal Scientia Halensis 3/2003, 5-6.

Brandenburg, K., Garidel, P., Andrä, J., Jürgens, G., Müller, M., Blume, A., Koch, M.H.J., Levin, J. (2003)
Cross-linked hemoglobin converts endotoxically inactive pentaacyl endotoxins into a physiologically active conformation, J. Biol. Chem.278, 47660-47669.

Hildebrand, A., Beyer, K., Neubert, R., Garidel, P. Blume, A. (2003)
Temperature dependence of the interaction of cholate and deoxycholate with fluid model membranes and their solubilization into mixed micelles. Colloids and Surfaces B 32, 335-351.

Cheng, X.H, Prehm, M., Das, M.K., Kain, J., Baumeister, U., Diele, S., Leine, D., Blume, A., Tschierske, C. (2003)
Calamitic bolaamphiphiles with (semi)perfluorinated lateral chains: Polyphilic block molecules with new liquid crystalline phase structures. J. Amer. Chem. Soc. 125, 10977-10996

Hait, S.K., Majhi, P.R., Blume, A., Moulik, S.P. (2003)
A Critical Assessment of Micellization of Sodium Dodecyl Benzene Sulfonate (SDBS) and its Interaction with PVP and Hydrophobically Modified Polymers, JR400 and LM 200. J. Phys. Chem. B. 107, 3650-3658.

Garidel, P., Hauser, A., Förster, G., Blume, A., Rapp, G. (2002)
N-Stearoyl-Phytosphingosine Lipid Organisation as Observed by Synchrotron X-Ray and Atomic Force Microscopy. Hasylab Annual Report 2002, 831-832.

Förster, G., Blume, A., Garidel, P., Dobner, B., Rapp, G. (2002)
Unusual Gel Phase Structures in Bola-PCs With Different Headgroups. Hasylab Annual Report 2002, 925-926.

Brandenburg, K., Jürgens, G., Andrä, J., Lindner, B., Koch, M.H.J., Blume, A., Garidel, P. (2002)
Biophysical characterization of the interaction of high-density lipoprotein (HDL) with endotoxins. Eur. J. Biochem. 269, 5972-5981.

Majhi, P.R., Blume, A. (2002)
Temperature-induced Micelle-Vesicle Transitions in Phospholipid-Surfactant Mixtures. J. Phys. Chem. B, 106, 10753-10763.

Jürgens, G., Müller, M., Garidel, P., Koch, M.H.J., Nakakubo, H., Blume, A., Brandenburg, K. (2002)
Investigation into the interaction of recombinant human serum albumin with Re-lipopolysaccharide and lipid A. J. Endotoxin Res. 8, 115-126.

Hildebrand, A., Neubert, R., Garidel, P., Blume, A. (2002)
Bile salt induced solubilization of synthetic phosphatidylcholine vesicles studied by means of isothermal titration calorimetry. Langmuir 18, 2836-2847.

Fitter, J., Herrmann, R., Dencher, N.A., Blume, A., Hauß, T. (2001)
Activity and Stability of a Thermostable a-Amylase Compared to its Mesophilic Homologue: Mechanisms of Thermal Adaptation. Biochemistry 40, 10723-10731.

Garidel, P., Hauser, A., Förster, G., Blume, A., Rapp, G. (2001)
The Gel Phase Structure of Hydrated Ceramide 3b as Investigated by Synchrotron X-Ray and Atomic Force Microscopy. Hasylab Annual Report 2001, 707-708.

Garidel, P., Förster, G., Blume, A., Richter, W., Rapp, G. (2001)
The Formation of Cochleate Structures. Hasylab Annual Report 2001, 705-706.

Förster, G., Meister, A., Blume, A. (2001)
Chain packing modes in crystalline surfactant and lipid bilayers. Curr. Opin. Coll. Interf. Sci. 6, 294-302.

Majhi, P.R., Blume, A. (2001)
Thermodynamic characterization of temperature induced micellization and demicellization of detergents studied by DSC. Langmuir 17, 3844-3851.

Garidel, P., Richter, W., Rapp, G., Blume, A. (2001)
Structural and morphological investigations of the formation of quasi-crystalline 1,2-dimyristoyl-sn-glycero-3-phosphoglycerol (DMPG) phases. Phys. Chem. Chem. Phys. 3, 1504-1513.

Garidel, P., Johann, C., Blume, A. (2000)
Thermodynamics of lipid organization and domain formation in phospholipid bilayers. J. Liposome Res. 10, 131-158.

Hauser, A., Garidel, P., Förster, G., Blume, A. (2000)
Atomic Force Microscopic Investigations of the Gel Phase of Phosphatidylcholines Containing w-Cyclohexyl Fatty Acids. Phys. Chem. Chem. Phys. 2, 4554-4558.

Förster, G., Meister, A., Blume, A. (2000)
Van der Waals Energy Contour Map Describing the Orthorhombic Hydrocarbon Chain Packing of Symmetry Pbnm. Phys. Chem. Chem. Phys. 2, 4503-4508.

Kerth, A., Gericke, A., Blume, A. (2000)
IRRAS study of phosholipid monolayers containing BMP or Ganglioside GM1. Eur. Biophys. J. 29, 291.

Garidel, P., Förster, G., Richter, W., Kunst, B. H., Rapp, G., Blume, A. (2000)
DMPG Divalent Cation Complexes: An X-Ray Scattering and Freeze-Fracture-Electron-Microscopic Study. Phys. Chem. Chem. Phys. 2, 4537-4544.

Meister, A., Förster, G., Blume, A. (2000)
Energy Calculations Related to Aliphatic Chain-Packing Modes. Progr. Coll. Polym. Sci. 115, 259-264.

Garidel, P., Hildebrand, A., Neubert, R., Blume, A. (2000)
Thermodynamic characterization of bile salt micelle formation as a function of temperature and ionic strength using isothermal titration calorimetry. Langmuir 16, 5267-5275.

Garidel, P., Hübner, W., Blume, A. (2000)
FT-IR spectroscopic investigations of the interactions of divalent alkaline earth cations with dimyristoyl-phosphatidyl-glycerol. Biochim. Biophys. Acta 1466, 245-259

Kern, H., Choi, S., Wenz, G., Erhard, L., Heinrich, J., Mischnick, P., Garidel, P., Blume, A. (2000)
Synthesis, Control of Substitution Pattern and Phase Transitions of 2,3-Di-O-methyl-cellulose. Carbohydr. Res. 326, 67-79.

Garidel, P., Blume, A. (2000)
Calcium induced nonideal mixing in liquid-crystalline phosphatidylcholine-phosphatidic acid bilayer membranes. Langmuir 16, 1662-1667.

Garidel, P., Blume, A. (2000)
The mixing behavior of pseudobinary phosphatidylethanolamine-phosphatidylglycerol mixtures as a function of pH and acyl chain length. Eur. Biophys. J. 28, 629-638.

(nach oben)

1990 - 1999

Gericke, A., Kerth, A., Blume, A. (1999)
Infrared spectroscopic investigation of lipid and protein monolayers at the air/water interface. Bruker Application Note #51, pp 1-10.

Blume, A., Garidel, P. (1999)
in: Handbook of Thermal Analysis and Calorimetry, Vol 4.: “From Macromolecules to Man.” (R.B. Kemp, Ed.) Chpt. 3, “Lipid Model Membranes and Biomembranes.” Elsevier Press, Amsterdam, pp. 109-173.

Garidel, P., Blume, A. (1999)
The Interaction of Alkaline Earth Cations with the Negatively Charged Phospholipid 1,2-Dimyristoyl-sn-glycero-3-phosphoglycerol: A Differential Scanning and Isothermal Titration Calorimetric Study. Langmuir 15, 5526-5534.

Giehl, A., Lemm, T., Bartelsen, O., Sandhoff, K., Blume, A. (1999)
Interaction of the GM2-activator protein with phospholipid/ganglioside bilayer membranes and with monolayers at the air/water interface. Eur. J. Biochem. 261, 650-658.

Garidel, P., Johann, C., Blume, A. (1998)
Induction of fluid-fluid immiscibility in phospholipid model membranes: a calorimetric study and thermodynamic analysis. J Liposome Res 8, 58-59.

Hübner, W., Blume, A. (1998)
Interactions at the Lipid-Water-Interface. Chem. Phys. Lipids 96, 99-123.

Garidel, P., Blume, A. (1998)
Miscibility of phospholipids with identical headgroups and acyl chain lengths differing by two methylene units: Effects of headgroup structure and headgroup charge. Biochim. Biophys. Acta 1371, 83-95.

Blume, A. (1998)
Phospholipid-Ligand Interactions. In: Biocalorimetry: Applications of Calorimetry in the Biological Sciences (J.E. Ladbury, B. Z. Chowdhry, Eds.) Wiley, Chichester, Chapter 5, pp 77-88.

Merk, S., Blume, A., Riederer, M., (1998)
Phase behaviour and crystallinity of plant cuticular waxes studied by Fourier transform infrared spectroscopy. Planta 204, 44-53.

Garidel, P., Johann, C., Mennicke, L., Blume, A. (1997)
The Mixing Behaviour of Pseudobinary Phosphatidylcholine-Phosphatidylglycerol Mixtures as a Function of pH and Chain Length. Eur. Biophys. J. 26, 447-459.

Garidel, P., Johann, C., Blume, A. (1997)
Non-ideal Mixing and Phase Separation in Phosphatidylcholine-Phosphatidic Acid Mixtures as a Function of pH and Chain Length. Biophys. J. 72, 2196-2210.

Keller, M., Kerth, A., Blume, A. (1997)
Thermodynamics of Interaction of Octyl-glucoside with Phosphatidylcholine Vesicles: Partitioning and Solubilization as Studied by High Sensitivity Titration Calorimetry. Biochim. Biophys. Acta 1326, 178-192.

Heerklotz, H., Binder, H., Lantzsch, G., Klose, G., Blume, A. (1997)
Lipid/Detergent Interaction Thermodynamics as a Function of Molecular Shape. J. Phys. Chem. 101, 639-645.

Johann, C., Garidel, P., Mennicke, L., Blume, A. (1996)
New Approaches to the Simulation of Heat-Capacity Curves and Phase Diagrams of Pseudobinary Phospholipid Mixtures. Biophys. J. 71, 3215-3228.

Müller, E., Giehl, A., Sandhoff, K., Schwarzmann, G., Blume, A. (1996)
Oriented 1,2-Dimyristoyl-sn-glycero-3-phosphorylcholine/Ganglioside Membranes: A Fourier Transform Infrared Attenuated Total Reflection Spectroscopic Study. Band Assignments; Orientational, Hydrational, and Phase Behavior; and Effects of Ca2+ Binding. Biophys. J. 71, 1400-1421.

Heerklotz, H., Lantzsch, G., Binder, H., Klose, G., Blume, A. (1996)
Thermodynamic Characterization of Dilute Aqueous Lipid/Detergent Mixtures of POPC and C12EO8 by Means of Isothermal Titration Calorimetry. J. Phys. Chem. 100, 6764-6774.

Blume, A. (1996)
Water Permeability of Lipid Bilayers. Skin Pharmacol. 9, 79.

Blume, A. (1996)
Properties of Lipid Vesicles: FT-IR-Spectroscopy and Fluorescent Probe Studies. Curr. Opin. Coll. Interf. Sci. 1, 64-77.

Milhaud, J., Lancelin, J.M., Michels, B., Blume, A. (1996)
Association of Polyene Antibiotics with Sterol-free Lipid Membranes." I. Hydrophobic Binding of Filipin to Dimyristoylphosphatidylcholine Bilayers. Biochim. Biophys. Acta.1278, 223-232.

Ziegler, W., Blume, A. (1995)
Acyl Chain Conformational Ordering of Individual Components in Liquid-Crystalline Bilayers of Mixtures of Phosphatidylcholines and Phosphatidic Acids: A Comparative FT-IR and 2H-NMR Study. Spectrochim. Acta, Part A, 51, 1763-1778.

Giehl, A., Müller, E., Blume, A., Sandhoff, K., Schwarzmann, G. (1995)
FT-IR-ATR Spectroscopy of Oriented Phospholipid-Ganglioside Bilayers in “Spectroscopy of Biological Molecules” (J.C. Merlin, S. Turell, J.P. Huvenne, Eds.) Kluwer Academic Publishers, Dordrecht, p. 371-372

Paula, S., Süs, W., Tuchtenhagen, J., Blume, A. (1995)
"Thermodynamics of Micelle Formation as a Function of Temperature: A High Sensitivity Titration Calorimetry Study. J. Phys. Chem. 99, 11742-11751.

Heerklotz, H., Lantzsch, G., Binder, H., Klose, G., Blume, A. (1995)
Application of Isothermal Titration Calorimetry for Detecting Lipid Membrane Solubilization. Chem. Phys. Lett. 235, 517-520.

Jansen, M., Blume, A. (1995)
A Comparative Study of Diffusive and Osmotic Water Permeation Across Bilayers Composed of Phospholipids With Different Head Groups and Fatty Acyl Chains. Biophys. J. 68, 997-1008.

Tuchtenhagen, J., Ziegler, W., Blume, A. (1994) Acyl Chain Conformational Ordering in Liquid-Crystalline Bilayers: Comparative FT-IR and 2H-NMR Studies of Phospholipids Differing in Head Group Structure and Chain Length. Eur. Biophys. J. 23, 323-335.

Gerdon, S., Hofmann, S., Blume, A. (1994)
Properties of Mixed Monolayers and Bilayers of Long Chain 5-n-Alkylresorcinols and Phosphatidylcholine. Chem. Phys. Lipids 71, 229-243.

Pax, H., Blume, A. (1993)
Polymerizable Phospholipids With Lipoic Acid as Head Group: Synthesis and Phase Properties. Chem. Phys. Lipids 66, 63-74.

Huang, T.-H., Lee, C.W.B., Das Gupta, S.K., Blume, A., Griffin, R.G. (1993)
A 13C and 2H Nuclear Magnetic Resonance Study of Phosphatidylcho­line/Cholesterol Interactions. Characterization of Liquid-Gel Phases. Biochemistry 32, 13277-13287.

Blume, A., Jansen, M., Ghyczy, M., Gareiß, J., (1993)
Interaction of Phospholipid Liposomes with Lipid Model Mixtures for Stratum Corneum Lipids. Intern. J. Pharm. 99, 219-228.

Blume, A., Tuchtenhagen, J., Paula, S. (1993)
Application of Titration Calorimetry to Study Binding of Ions, Detergents, and Polypeptides to Lipid Bilayers. Progr. Coll. Polymer Sci., 93, 118-122.

Müller, E., Blume, A. (1993)
FT-IR-spectroscopic Analysis of the Amide and Acid Bands of Ganglioside GM1 in Pure Form and in Mixtures with DMPC. Biochim. Biophys. Acta 1146, 45-51.

Blume, A. (1993)
n "Phospholipids Handbook" (G. Cevc, Ed.) Marcel Dekker, New York, 1993, "Dynamic Properties" Chpt. 13, pp 455-509.

Davies, M.A., Hübner, W., Blume, A., Mendelsohn, R. (1992)
Acyl Chain Conformational Ordering in 1,2 Dipalmitoylphosphatidylethanolamine. Integration of FT-IR and 2H-NMR Results. Biophys. J. 63, 1059-1062.

Blume, A. (1992)
Phospholipids as Basic Ingredients. Liposome Dermatics, (O. Braun-Falco, H.C.Korting, H.I.Maibach, Eds.) Springer Verlag, Berlin, pp. 29-37.

Blume, A., Tuchtenhagen, J. (1992)
Thermodynamics of Ion Binding to Phospholipid Bilayers. Titration Calorimetry of the Heat of Dissociation of DMPA. Biochemistry 31, 4636-4642.

Blume, A. (1991)
Biological Calorimetry: Membranes. Thermochim. Acta 193, 299-347.

Müller, E., Kopp, E., Blume, A. (1991)
FT-IR-Spectroscopic Studies of Ganglioside GM1/Phospholipid Mixtures. Spectroscopy of Biological Molecules (R.E. Hester und R.B. Girling, Eds.), The Royal Society of Chemistry, Cambridge, pp 189-190.

Tuchtenhagen, J., Blume, A., (1991)
FT-IR and Calorimetric Studies of Ion Binding to Negatively Charged Phospholipids. Spectroscopy of Biological Molecules (R.E. Hester und R.B. Girling, Hrsg.). The Royal Society of Chemistry, Cambridge, pp 167-168.

Blume, A., (1991)
Phase Transitions of Polymerizable Phospholipids. Chem. Phys. Lipids 57, 253-273.

Hübner, W., Blume, A. (1990)
2H-NMR-Studies of Oriented Phospholipid Bilayers in the Gel Phase. J. Phys. Chem. 94, 7726-7730.

Stöppelmann, G., Gronski, W., Blume, A. (1990)
Motional Heterogeneity and the Nature of the Interphase in Blockcopolymers. A 2H Nuclear Magnetic Resonance Study. Polymer 31, 1838-1853.

Manosroi, A., Blume, A., Manosroi, J., Bauer, K.H. (1990)
Thermodynamic Characteristics of a Human Insulin-DEAE-Dextran Complex Entrapped in Liposomes. Drug. Devel. Ind. Pharm., 16, 837-854.

(nach oben)

1973 - 1989

Blume, A., Bäuerle, H.D. (1989)
FT-IR- and 2H-NMR Studies of Lipid Model Membranes Composed of Lipids with Branched-Chain and w-Cyclohexyl Fatty Acids. Spectroscopy of Biological Molecules: State of the Art (A. Bertoluzza, C. Fagnano und P. Monti, Eds.) Societa Editrice Esculapio, Bologna, pp. 235-236.

Staatz, I., Granzer, U.H., Blume, A., Roth, H.J. (1989)
Synthese und Aggregationsverhalten chiraler Cystein-Amphiphile mit s-Triazin als verknüpfende Partialstruktur. Liebigs Ann. Chem. 1989, 127-131.

Gronski, W., Stöppelmann, G., Blume, A. (1988)  
Dynamics at the Interface of Blockcopolymers as Observed by 2H-NMR. Polym. Prepr. ACS , Div. Polym. Chem. 11, 400.

Blume, A., Hübner, W., Müller, M., Bäuerle, H.D. (1988)
Structure and Dynamics of Lipid Model Membranes: FT-IR and 2H-NMR-Spectroscopic Studies. Ber. Bunsenges. Phys. Chem. 92, 964-973

Blume, A., Hübner, W., Messner, G. (1988)
Fourier Transform Infrared Spectroscopy of 13C=O Labeled Phospholipids. Hydrogen Bonding to Carbonyl Groups. Biochemistry 27, 8239-8249.

Huang, T.H., Blume, A., DasGupta, S.K., Griffin, R.G. (1988)
Nuclear Magnetic Resonance and Calorimetric Study of the Structure, Dynamics and Phase Behavior of Uranyl Ion/Dipalmitoylphosphatidylcholine Complexes. Biophys. J. 54, 173-179.

Hübner, W., Blume, A. (1988) FT-IR and 2H-NMR-Spectroscopic Investigations of 2H-Labeled Phospholipids Spectroscopy of Biological Molecules - New Advances, (E.D.Schmid, F.W.Schneider und F.Siebert, Eds.) John Wiley, New York, pp. 161-164.

Blume, A., Hübner, W. (1988)  
FT-IR Spectroscopic Investigations of 13C-Labeled Phospholipids. Spectroscopy of Biological Molecules - New Advances, (E.D.Schmid, F.W.Schneider und F.Siebert, Eds.) John Wiley, New York, pp. 157-160.

Blume, A. (1988)
Physical Properties of Biological Membranes and Their Functional Implications. 2H and 13C-NMR-Spectroscopy of Lipid Model Membranes. (C. Hidalgo, Ed.), Plenum Press, New York, pp. 21-70.

Blume, A. (1988)
Physical Properties of Biological Membranes and Their Functional Implications, Applications of Calorimetry to Lipid Model Membranes. (C. Hidalgo, Ed.) Plenum Press, New York, pp. 71-121.

Hübner, W., Blume, A. (1987)
2H-NMR-Spectroscopic Investigations of Phospholipid Bilayers. Ber. Bunsenges. Phys. Chem., 91, 1127-1132.

Brandenburg, K., Blume, A. (1987)
Investigations into the Thermotropic Phase Behavior of Natural Membranes Extracted from Gram-negative Bacteria and Artificial Membrane Systems Made from Lipopolysaccharides and Free Lipid A. Thermochim. Acta, 119, 127- 142.

Blume, A., Habel, K., Frey, T., Finke, A., (1987)
DSC-Studies of Phospholipids with Iso-branched and w-Cyclohexane Fatty Acids. Thermochim. Acta, 114, 53-58.

Blume, A., Hillmann, M. (1986)
Dimyristoyl Phosphatidic Acid/Cholesterol Bilayers. Thermodynamic Properties and Kinetics of the Phase Transition as Studied by the Pressure Jump Relaxation Technique. Eur. Biophys. J. 13, 343-353.

Kannenberg, E., Blume, A., McElhaney, R.N., Poralla, K. (1986)
Mixed Monolayer Studies of the Interactions of Synthetic Phosphatidylcholines Containing Branched Fatty Acids and a Hopane Glykolipid Isolated from the Thermo-Acidophilic Bacterium Bacillus Acidocaldarius. Chem. Phys. Lipids 39, 145-153.

Blume, A., (1986)
Lipid Phase Transitions: Water and Proton Permeability. Methods in Enzymology, Vol. 127, pp. 480-486.

Blume, A., Hübner, W., Messner, G. (1985)
Biological Membranes and Other Liquid Crystals. . FT-IR-Spectroscopic Investigations of Isotopically Labeled Lipids and Lipid Mixtures. Proceedings of the Joint Meeting of The British Radiofrequency Spectroscopy Group and the British Liquid Crystal Group on. Southampton, 1985

Blume, A. (1985)
Calorimetry of Lipid Model Membranes. Thermochimica Acta 85, 469-472.

Kannenberg, E., Blume, A., Geckeler, K., Poralla, K. (1985)
Properties of Hopanoids and Phosphatidylcholine Containing w-Cyclohexane Fatty Acid in Monolayer and Liposome Experiments. Biochim. Biophys. Acta 814, 179-185.

Kannenberg, E., Blume, A., Poralla, K. (1985)
Properties of w-Cyclohexane Fatty Acids in Membranes. FEBS-Letters 172, 331-334.

Elamrani, K., Blume, A. (1984)
Phase Transition Kinetics of Phosphatidic Acid Bilayers. A Stopped-Flow-Study of the Electrostatically Induced Transition. Biochim. Biophys. Acta 769, 578-584.

Meier, P., Ohmes, E., Kothe, G., Blume, A., Weidner, J. Eibl, H. (1983)
Molecular Order and Dynamics of Phospholipid Membranes: A Deuteron Magnetic Resonance Study Employing a Comprehensive Lineshape Model. J. Phys. Chem. 87, 4904-4912.

Kannenberg, E., Blume, A., McElhaney, R.N., Poralla, K. (1983)
Monolayer and Calorimetric Studies of Phosphatidylcholines Containing Branched- Chain Fatty Acids and of Their Interactions With Cholesterol and With a Bacterial Hopanoid in Model Membranes. Biochim. Biophys. Acta 733, 111-116.

Blume, A. (1983)
Apparent Molar Heat Capacities of Phospholipids in Aqueous Dispersion. Effects of Chain Length and Head Group Structure. Biochemistry 22, 5436-5442.

Elamrani, K., Blume, A. (1983)
Phase Transition Kinetics of Phosphatidic Acid Bilayers. A Pressure Jump Relaxation Study. Biochemistry 22, 3305-3311

Elamrani, K., Blume, A. (1983)
Effect of the Lipid Phase Transition on the Kinetics of H+/OH--Diffusion Across Phosphatidic Acid Bilayers. Biochim. Biophys. Acta 727, 22-30.

Blume, A., Wittebort, R.J., DasGupta, S.K., Griffin, R.G. (1982)
Phase Equilibria, Molecular Conformation, and Dynamics in Phosphatidylcholine/ Phosphatidyl-ethanolamine Bilayers. Biochemistry 21, 6243-6253.

Blume, A., Griffin, R.G. (1982)
Carbon-13 and Deuterium Nuclear Magnetic Resonance Study of the Interaction of Cholesterol with Phosphatidylethanola­mine. Biochemistry 21, 6230-6242.

Blume, A., Rice, D.M., Wittebort, R.J., Griffin, R.G. (1982)
Molecular Dynamics and Conformation in the Gel and Liquid-Crystalline Phases of Phosphatidylethanolamine Bilayers. Biochemistry 21, 6220-6230.

Wittebort, R.J., Blume, A., Huang, T.H., DasGupta, S.K., Griffin, R.G. (1982)
Carbon-13 Nuclear Magnetic Resonance Investigations of Phase Transitions and Phase Equilibria in Pure and Mixed Phospholipid Bilayers. Biochemistry 21, 3487-3502.

Meier, P., Blume, A., Ohmes, E., Neugebauer, F., Kothe, G. (1982)
Structure and Dynamics of Phospholipid Membranes: An Electron Spin Resonance Study Employing Biradical Probes. Biochemistry 21, 526-534.

Elamrani, K., Blume, A. (1982)
Incorporation Kinetics of Lysolecithin into Lecithin Vesicles. Kinetics of Lysolecithin Induced Vesicle Fusion. Biochemistry 21, 521-526.

Heyn, M., Blume, A., Rehorek, M., Dencher, N. (1981)
Calorimetric and Fluorescence Depolarization Studies on the Lipid Phase Transition of Bacteriorhodopsin-Dimyristoyl-phosphatidylcholine Vesicles. Biochemistry 20, 7109-7115.

Rice, D.M., Blume, A., Herzfeld, J., Wittebort, R.J., DasGupta, S.K., Griffin, R.G (1981) Solid State NMR Investigations of Lipid Bilayers, Peptides and Proteins. in Proceedings of the Second SUNYA Conversation (R.H.Sarma, ed.) Vol. II, pp.255-270, Adenine Press, New York.

Blume, A., Eibl, H. (1981)
A Calorimetric Study of the Thermotropic Behavior of 1,2-Dipentadecylmethylidene Phospholipids. Biochim. Biophys. Acta 640. 609-618.

Blume, A. (1980)
Thermotropic Behavior of Phosphatidylethanolamine-Cholesterol and Phosphatidylethanolamine-Phosphatidylcholine Cholesterol Mixtures. Biochemistry 19, 4908-4913.

Kannenberg, E., Poralla, K., Blume, A. (1980)
A Hopanoid from the Thermo-acidophilic Bacillus acidocaldarius Condenses Membranes. Naturwiss. 67, 458-459.

Poralla, K., Kannenberg, E., Blume, A. (1980)
A Glykolipid Containing Hopane Isolated from the Acidophilic, Thermophilic Bacillus acidocaldrius Has a Cholesterol-like Function in Membranes. FEBS-Letters 113, 107-110.

Gruenewald, B., Blume, A., Watanabe, F. (1980)
Kinetic Investigations on the Phase Transition of Lecithin Bilayers. Biochim. Biophys. Acta 597, 41-52.

Blume, A. Eibl, H. (1979)
The Influence of Charge on Bilayer Membranes. Calorimetric Investigations of Phosphatidic Acid Bilayers. Biochim. Biophys. Acta 558, 13-21.

Blume, A., (1979)
The Influence of Dioxan on the Bilayer and Monolayer Phase Transition of Phospholipids. Biophys. Chem. 10, 371-378.

Blume, A., (1979)
A Comparative Study of the Phase Transition of Phospholipid Bilayers and Monolayers. Biochim. Biophys. Acta 557, 32-44.

Gruenewald, B., Stankovski, S. Blume, A. (1979)
Curvature Influence on the Cooperativity and the Phase Transition Enthalpy of Lecithin Vesicles. FEBS-Letters 102, 227-229.

Eibl, H., Blume, A., (1979)
The Influence of Charge on Phosphatidic Acid Bilayer Membranes. Biochim. Biophys. Acta 553, 467- 488.

Blume, A., Dreher, R., Poralla, K., (1978)
The Influence of Branched-chain and w-alicyclic Fatty Acids on the Transition Temperature of Bacillus subtilis Lipids. Biochim. Biophys. Acta 512, 489-494.

Weltzien, H.U., Arnold, B., Blume, A., Kalkoff, H.G., (1976)
Molecular Aggregation of the Slow Reacting Hemolytic Lysolecithin Analog 1-Octadecyl-2-benzyl-glycero-3-phosphorylcholine in Aqueous Solution. Chem. Phys. Lipids 16, 267-275.

Blume, A., Arnold, B., Weltzien, H.U., (1976)
Effects of a Synthetic Lysolecithin Analog on the Phase Transition of Mixtures of Phosphatidylethanolamine and Phosphatidylcholine. FEBS-Letters 61, 199-202.

Wunderlich, F., Ronai, A., Speth, V., Seelig, J., Blume, A., (1975)
Thermotropic Lipid Clustering in Tetrahymena Membranes. Biochemistry 14, 3730-3735.

Bode, W., Hinz, H., Jaenicke, R. Blume, A., (1974)
Calorimetric Studies of the in vitro Polymerization of Proteus mirabilis Flagellin. Biophys. Struct. Mechanism 1, 55-64.

Blume, A., Ackermann, Th. (1974)
A Calorimetric Study of the Lipid Phase Transition in Aqueous Dispersions of Phosphorylcholine-Phosphorylethanolamine Mixtures. FEBS-Letters 43, 71-74.

Bode, W., Blume, A. (1973).
Thermal Transitions of Proteus mirabilis Flagellin as Studied by Circular Dichroism and Adiabatic Differential Scanning Calorimetry. FEBS-Letters 36, 318-322

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