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Publications

2025

Mapping Selective Oxidations of Unspecific Peroxygenases   
Dominik Homann, Pascal Püllman, Martin J Weissenborn
ChemCatChem, 2025, 0, e00082

2024

Rubber Oxygenase Degradation Assay by UV-Labeling and Gel Permeation Chromatography
   Vico K. B. Adjedje, Yannick L. Wolf, Martin J. Weissenborn, Wolfgang H. Binder,
Macromolecular Rapid Communications, 2024, 45, 2400032

Functionally Diverse Peroxygenases by AlphaFold2, Design, and Signal Peptide Shuffling   .
Judith Münch, Niklas Dietz, Shiran Barber-Zucker, Franziska Seifert, Susanne Matschi, Pascal Püllmann, Sarel J. Fleishman*, Martin J. Weissenborn*
ACS Catalysis, 2024, 14, 4738−4748

A computationally designed panel of diverse and selective peroxygenases for terpene oxyfunctionalization   .
   Judith Munch, Jordi Soler, Sarel Fleishman, Marc Garcia-Borras, Martin J Weissenborn*
BioRXiv, doi.org/10.1101/2024.09.27.615329

2023

Light‐Controlled Biocatalysis by Unspecific Peroxygenases with Genetically Encoded Photosensitizers
   Pascal Püllmann, Dominik Homann, Tobias A. Karl, Burkhard König, Martin J. Weissenborn
Angewandte Chemie Volume 62, Issue 41

Computational-Aided Engineering of a Selective Unspecific Peroxygenase toward Enantiodivergent β-Ionone  Hydroxylation
   J Münch, J Soler, N Hünecke, D Homann, M Garcia-Borràs, Martin J Weissenborn
ACS Catalysis 13, 8963-8972

A Career in Catalysis: Bernhard Hauer
   Bernd A Nebel, Michael Breuer, Andreas Schneider, Benjamin Aberle,  Stephan C Hammer, Per-Olof Syrén, Martin J Weissenborn, Bettina M Nestl
ACS Catalysis 13, 8861-8889

2022

YfeX–a new platform for carbene transferase development with high intrinsic reactivity
   Victor Sosa Alfaro, Sodiq O Waheed, Hannah Palomino, Anja Knorrscheidt, Martin Weissenborn, Christo Z Christov, Nicolai Lehnert
Chemistry–A European Journal 28 (65), e202201474

Valorization of small alkanes by biocatalytic oxyfunctionalization
   Durga Mahor, Zhiqi Cong, Martin J Weissenborn, Frank Hollmann, Wuyuan Zhang
ChemSusChem 15 (9), e202101116

2021

Enzymatic Hydroxylations of sp³-Carbons
   J Münch, P Püllmann, W Zhang, MJ Weissenborn
ACS Catalysis 11 (15), 9168-9203

Accessing chemo-and regioselective benzylic and aromatic oxidations by protein engineering of an unspecific peroxygenase
   Anja Knorrscheidt, Jordi Soler, Nicole Hünecke, Pascal Püllmann, Marc Garcia-Borràs, Martin J Weissenborn
ACS catalysis 11 (12), 7327-7338

Improving the Heterologous Production of Fungal Peroxygenases through an Episomal Pichia pastoris Promoter and Signal Peptide Shuffling System
   P Püllmann, MJ Weissenborn
ACS Synthetic Biology 10 (6), 1360-1372

A modular two yeast species secretion system for the production and preparative application of unspecific peroxygenase   s   
Pascal Püllmann, Anja Knorrscheidt, Judith Münch, Paul R Palme, Wolfgang  Hoehenwarter, Sylvestre Marillonnet, Miguel Alcalde, Bernhard  Westermann, Martin J Weissenborn
Communications biology 4 (1), 562

Enzymatic degradation of synthetic polyisoprenes via surfactant-free polymer emulsification  
   VKB Adjedje, E Schell, YL Wolf, A Laub, MJ Weissenborn, WH Binder
Green Chemistry 23 (23), 9433-9438

Simultaneous  screening of multiple substrates with an unspecific peroxygenase  enabled modified alkane and alkene oxyfunctionalisations
   Anja Knorrscheidt, Jordi Soler, Nicole Hünecke, Pascal Püllmann, Marc Garcia-Borràs, Martin J Weissenborn
Catalysis Science & Technology 11 (18), 6058-6064

2020

Identification  of novel unspecific peroxygenase chimeras and unusual YfeX axial heme  ligand by a versatile high-throughput GC-MS approach
   Anja Knorrscheidt, Pascal Püllmann, Eugen Schell, Dominik Homann, Erik Freier, Martin J. Weissenborn
ChemCatChem

Iron‐porphyrin  catalyzed carbene transfer reactions–an evolution from biomimetic  catalysis towards chemistry‐inspired non‐natural reactivities of enzymes
   MJ Weissenborn, RM Koenigs
ChemCatChem 12, 2171-2179

2019

Pilzliche Peroxygenasen: der Schlüssel zu CH-Hydroxylierungen und mehr?
   P Püllmann, MJ Weissenborn
BIOspektrum 25, 572-574

Golden Mutagenesis: An efficient multi-site saturation mutagenesis approach by Golden Gate cloning with automated primer design
   Pascal Puellmann, Chris Ulpinnis, Sylvestre Marillonnet, Ramona Gruetzner, Steffen Neumann, Martin J Weissenborn
Scientific Reports 9

Tryptamine synthesis by iron porphyrin catalyzed C− H functionalization of indoles with diazoacetonitrile
   Katharina J Hock, Anja Knorrscheidt, Renè Hommelsheim, Junming Ho, Martin J Weissenborn, Rene M Koenigs
Angewandte Chemie International Edition 58 (11), 3630-3634

2018

Modulating proposed electron transfer pathways in P450BM3 led to improved activity and coupling efficiency
   D Darimont, MJ Weissenborn, BA Nebel, B Hauer
Bioelectrochemistry 119, 119-123

2017

Tackling the numbers problem: Entwicklung nicht-nativer Enzymreaktionen
   M Kammel, A Knorrscheidt, P Püllmann, MJ Weissenborn
BIOspektrum 23, 830-832

Development  of a solid phase array assay for the screening of galactose oxidase  activity and for fast identification of inhibitors
   MJ Weissenborn, DP Debecker, S Golten, B Linclau, NJ Turner, SL Flitsch
Protein and peptide letters 24 (8), 742-746

2016

Structure‐Guided Redesign of CYP153A_M.aq for the Improved Terminal Hydroxylation of Fatty Acids
   Sara M Hoffmann, Hamid‐Reza Danesh‐Azari, Claudia Spandolf, Martin J Weissenborn, Gideon Grogan, Bernhard Hauer
ChemCatChem 8 (20), 3234-3239

Enhanced Ene‐Reductase Activity through Alteration of Artificial Nicotinamide Cofactor Substituents
   SA Löw, IM Löw, MJ Weissenborn, B Hauer
ChemCatChem 8 (5), 911-915

Expanding  an efficient, electrically driven and CNT-tagged P450 system into the  third dimension: a nanowired CNT containing and enzyme stabilising 3D  sol-gel electrode
   Enrique C. Llaudet, Dominique Darimont, Ramona Samba, Ilona Matiychyn, Martin Stelzle, Martin J. Weissenborn, Bernhard Hauer

Redox Partner Interaction Sites in Cytochrome P450 Monooxygenases: In Silico Analysis and Experimental Validation
   Gricman, L, MJ Weissenborn, SM Hoffmann, N Borlinghaus, B Hauer, J Pleiss
ChemistrySelect

Whole-cell microtiter plate screening assay for terminal hydroxylation of fatty acids by P450s
   Martin J Weissenborn, Sandra Notonier, Sarah-Luise Lang, Konrad B Otte,  Susanne Herter, Nicholas J Turner, Sabine L Flitsch, Bernhard Hauer
Chemical Communications 52, 6158-6161

Enzyme-   Catalysed Carbonyl Olefination by the E. coli Protein YfeX in Absence of Phosphines
   Martin J. Weissenborn, Sebastian A. Löw, Niels Borlinghaus, Miriam Kuhn, Stefanie Kummer, Fabian Rami, Bernd Plietker
ChemCatChem

2015

Process Investigations on the One-Pot Synthesis of Rifamycin S Avoiding Chlorinated Solvents
   SA Löw, B Nestl, MJ Weissenborn, F Zepeck, B Hauer
Organic Process Research & Development 19, 1544-1547

2014

Glycosylation Characterization of Human and Porcine Fibrinogen Proteins by Lectin-   Binding Biophotonic Microarray Imaging
   RV Olkhov, MJ Weissenborn, SL Flitsch, AM Shaw
Analytical chemistry 86 (1), 621-628

2013

Profiling glycosyltransferase activities by tritium imaging of glycan microarrays
   Sonia Serna, Cornelis H Hokke, Martin Weissenborn, Sabine Flitsch, Manuel Martin‐Lomas, Niels‐Christian Reichardt
ChemBioChem 14 (7), 862-869

Enzymatic reactions on immobilised substrates
   CJ Gray, MJ Weissenborn, CE Eyers, SL Flitsch
Chemical Society Reviews 42 (15), 6378-6405

2012

Crystal structure of a soluble form of human CD73 with ecto‐5′‐nucleotidase activity
   Dominic PHM Heuts, Martin J Weissenborn, Rouslan V Olkhov, Andrew M Shaw, Jennet Gummadova, Colin Levy, Nigel S Scrutton
Chembiochem 13 (16), 2384-2391

Glycoarrays on Gold Surfaces
   P Both, R Sardzik, M Weissenborn, A Green, J Voglmeir, S Flitsch
Cracking the Sugar Code by Navigating the Glycospace, 93-105

Formation of carbohydrate-functionalised polystyrene and glass slides and their analysis by MALDI-TOF MS
   Martin J Weissenborn, Johannes W Wehner, Christopher J Gray, Robert  Šardzík, Claire E Eyers, Thisbe K Lindhorst, Sabine L Flitsch
Beilstein Journal of Organic Chemistry 8 (1), 753-762

Chemoenzymatic Synthesis of O-Mannosylpeptides in Solution and on Solid Phase
   Robert Sardzik, Anthony P Green, Nicolas Laurent, Peter Both, Carolina  Fontana, Josef Voglmeir, Martin J Weissenborn, Rose Haddoub, Paola  Grassi, Stuart M Haslam, Goran Widmalm, Sabine L Flitsch
Journal of the American Chemical Society 134 (10), 4521-4524

Dual purpose S-trityl-linkers for glycoarray fabrication on both polystyrene and gold
   Johannes W Wehner, Martin J Weissenborn, Mirja Hartmann, Christopher J  Gray, Robert Šardzík, Claire E Eyers, Sabine L Flitsch, Thisbe K  Lindhorst
Organic & biomolecular chemistry 10 (44), 8919-8926

Oxo-ester mediated native chemical ligation on microarrays: an efficient and chemoselective coupling methodology
   Martin J Weissenborn, Roberto Castangia, Johannes W Wehner, Robert Šardzík, Thisbe K Lindhorst, Sabine L Flitsch
Chemical Communications 48 (37), 4444-4446

2010

Enzymatic glycosylations on arrays
   J Voglmeir, R Šardzík, MJ Weissenborn, SL Flitsch
Omics: a journal of integrative biology 14 (4), 437-444

Preparation of aminoethyl glycosides for glycoconjugation
   R Šardzík, GT Noble, MJ Weissenborn, A Martin, SJ Webb, SL Flitsch
Beilstein journal of organic chemistry 6 (1), 699-703

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