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Publications

2024

Rubber Oxygenase Degradation Assay by UV-Labeling and Gel Permeation Chromatography   , Vico K. B. Adjedje, Yannick L. Wolf, Martin J. Weissenborn, Wolfgang H. Binder,
Macromolecular Rapid Communications, 2024, 45, 2400032

Functionally Diverse Peroxygenases by AlphaFold2, Design, and Signal Peptide Shuffling   , Judith Münch, Niklas Dietz, Shiran Barber-Zucker, Franziska Seifert, Susanne Matschi, Pascal Püllmann, Sarel J. Fleishman*, Martin J. Weissenborn*
ACS Catalysis, 2024, 14, 4738−4748

Mapping Selective Oxidations of Unspecific Peroxygenases   , Dominik Homann, Pascal Püllmann, Martin Weissenborn*
BioRXiv, doi.org/10.1101/2024.09.10.612301

A computationally designed panel of diverse and selective peroxygenases for terpene oxyfunctionalization   , Judith Munch, Jordi Soler, Sarel Fleishman, Marc Garcia-Borras, Martin J Weissenborn*
BioRXiv, doi.org/10.1101/2024.09.27.615329

2023

Light‐Controlled Biocatalysis by Unspecific Peroxygenases with Genetically Encoded Photosensitizers,    Pascal Püllmann, Dominik Homann, Tobias A. Karl, Burkhard König, Martin J. Weissenborn
Angewandte Chemie Volume 62, Issue 41

Computational-Aided Engineering of a Selective Unspecific Peroxygenase toward Enantiodivergent β-Ionone Hydroxylation,    J Münch, J Soler, N Hünecke, D Homann, M Garcia-Borràs, Martin J Weissenborn
ACS Catalysis 13, 8963-8972

A Career in Catalysis: Bernhard Hauer   , Bernd A Nebel, Michael Breuer, Andreas Schneider, Benjamin Aberle,  Stephan C Hammer, Per-Olof Syrén, Martin J Weissenborn, Bettina M Nestl
ACS Catalysis 13, 8861-8889

2022

YfeX–a new platform for carbene transferase development with high intrinsic reactivity   , Victor Sosa Alfaro, Sodiq O Waheed, Hannah Palomino, Anja Knorrscheidt, Martin Weissenborn, Christo Z Christov, Nicolai Lehnert
Chemistry–A European Journal 28 (65), e202201474

Valorization of small alkanes by biocatalytic oxyfunctionalization   , Durga Mahor, Zhiqi Cong, Martin J Weissenborn, Frank Hollmann, Wuyuan Zhang
ChemSusChem 15 (9), e202101116

2021

Enzymatic Hydroxylations of sp³-Carbons   , J Münch, P Püllmann, W Zhang, MJ Weissenborn
ACS Catalysis 11 (15), 9168-9203

Accessing chemo-and regioselective benzylic and aromatic oxidations by protein engineering of an unspecific peroxygenase   , Anja Knorrscheidt, Jordi Soler, Nicole Hünecke, Pascal Püllmann, Marc Garcia-Borràs, Martin J Weissenborn
ACS catalysis 11 (12), 7327-7338

Improving the Heterologous Production of Fungal Peroxygenases through an Episomal Pichia pastoris Promoter and Signal Peptide Shuffling System   , P Püllmann, MJ Weissenborn
ACS Synthetic Biology 10 (6), 1360-1372

A modular two yeast species secretion system for the production and preparative application of unspecific peroxygenases   , Pascal Püllmann, Anja Knorrscheidt, Judith Münch, Paul R Palme, Wolfgang  Hoehenwarter, Sylvestre Marillonnet, Miguel Alcalde, Bernhard  Westermann, Martin J Weissenborn
Communications biology 4 (1), 562

Enzymatic degradation of synthetic polyisoprenes via surfactant-free polymer emulsification   , VKB Adjedje, E Schell, YL Wolf, A Laub, MJ Weissenborn, WH Binder
Green Chemistry 23 (23), 9433-9438

Simultaneous  screening of multiple substrates with an unspecific peroxygenase  enabled modified alkane and alkene oxyfunctionalisations   , Anja Knorrscheidt, Jordi Soler, Nicole Hünecke, Pascal Püllmann, Marc Garcia-Borràs, Martin J Weissenborn
Catalysis Science & Technology 11 (18), 6058-6064

2020

Identification  of novel unspecific peroxygenase chimeras and unusual YfeX axial heme  ligand by a versatile high-throughput GC-MS approach   , Anja Knorrscheidt, Pascal Püllmann, Eugen Schell, Dominik Homann, Erik Freier, Martin J. Weissenborn
ChemCatChem

Iron‐porphyrin  catalyzed carbene transfer reactions–an evolution from biomimetic  catalysis towards chemistry‐inspired non‐natural reactivities of enzymes   , MJ Weissenborn, RM Koenigs
ChemCatChem 12, 2171-2179

2019

Pilzliche Peroxygenasen: der Schlüssel zu CH-Hydroxylierungen und mehr?   , P Püllmann, MJ Weissenborn
BIOspektrum 25, 572-574

Golden Mutagenesis: An efficient multi-site saturation mutagenesis approach by Golden Gate cloning with automated primer design   , Pascal Puellmann, Chris Ulpinnis, Sylvestre Marillonnet, Ramona Gruetzner, Steffen Neumann, Martin J Weissenborn
Scientific Reports 9

Tryptamine synthesis by iron porphyrin catalyzed C− H functionalization of indoles with diazoacetonitrile   , Katharina J Hock, Anja Knorrscheidt, Renè Hommelsheim, Junming Ho, Martin J Weissenborn, Rene M Koenigs
Angewandte Chemie International Edition 58 (11), 3630-3634

2018

Modulating proposed electron transfer pathways in P450BM3 led to improved activity and coupling efficiency   , D Darimont, MJ Weissenborn, BA Nebel, B Hauer
Bioelectrochemistry 119, 119-123

2017

Tackling the numbers problem: Entwicklung nicht-nativer Enzymreaktionen   , M Kammel, A Knorrscheidt, P Püllmann, MJ Weissenborn
BIOspektrum 23, 830-832

Development  of a solid phase array assay for the screening of galactose oxidase  activity and for fast identification of inhibitors   , MJ Weissenborn, DP Debecker, S Golten, B Linclau, NJ Turner, SL Flitsch
Protein and peptide letters 24 (8), 742-746

2016

Structure‐Guided Redesign of CYP153A_M.aq for the Improved Terminal Hydroxylation of Fatty Acids   , Sara M Hoffmann, Hamid‐Reza Danesh‐Azari, Claudia Spandolf, Martin J Weissenborn, Gideon Grogan, Bernhard Hauer
ChemCatChem 8 (20), 3234-3239

Enhanced Ene‐Reductase Activity through Alteration of Artificial Nicotinamide Cofactor Substituents   , SA Löw, IM Löw, MJ Weissenborn, B Hauer
ChemCatChem 8 (5), 911-915

Expanding  an efficient, electrically driven and CNT-tagged P450 system into the  third dimension: a nanowired CNT containing and enzyme stabilising 3D  sol-gel electrode   , Enrique C. Llaudet, Dominique Darimont, Ramona Samba, Ilona Matiychyn, Martin Stelzle, Martin J. Weissenborn, Bernhard Hauer

Redox Partner Interaction Sites in Cytochrome P450 Monooxygenases: In Silico Analysis and Experimental Validation   , Gricman, L, MJ Weissenborn, SM Hoffmann, N Borlinghaus, B Hauer, J Pleiss
ChemistrySelect

Whole-cell microtiter plate screening assay for terminal hydroxylation of fatty acids by P450s   , Martin J Weissenborn, Sandra Notonier, Sarah-Luise Lang, Konrad B Otte,  Susanne Herter, Nicholas J Turner, Sabine L Flitsch, Bernhard Hauer
Chemical Communications 52, 6158-6161

Enzyme-   Catalysed Carbonyl Olefination by the E. coli Protein YfeX in Absence of Phosphines   , Martin J. Weissenborn, Sebastian A. Löw, Niels Borlinghaus, Miriam Kuhn, Stefanie Kummer, Fabian Rami, Bernd Plietker
ChemCatChem

2015

Process Investigations on the One-Pot Synthesis of Rifamycin S Avoiding Chlorinated Solvents   , SA Löw, B Nestl, MJ Weissenborn, F Zepeck, B Hauer
Organic Process Research & Development 19, 1544-1547

2014

Glycosylation Characterization of Human and Porcine Fibrinogen Proteins by Lectin-   Binding Biophotonic Microarray Imaging   , RV Olkhov, MJ Weissenborn, SL Flitsch, AM Shaw
Analytical chemistry 86 (1), 621-628

2013

Profiling glycosyltransferase activities by tritium imaging of glycan microarrays   , Sonia Serna, Cornelis H Hokke, Martin Weissenborn, Sabine Flitsch, Manuel Martin‐Lomas, Niels‐Christian Reichardt
ChemBioChem 14 (7), 862-869

Enzymatic reactions on immobilised substrates   , CJ Gray, MJ Weissenborn, CE Eyers, SL Flitsch
Chemical Society Reviews 42 (15), 6378-6405

2012

Crystal structure of a soluble form of human CD73 with ecto‐5′‐nucleotidase activity   , Dominic PHM Heuts, Martin J Weissenborn, Rouslan V Olkhov, Andrew M Shaw, Jennet Gummadova, Colin Levy, Nigel S Scrutton
Chembiochem 13 (16), 2384-2391

Glycoarrays on Gold Surfaces   , P Both, R Sardzik, M Weissenborn, A Green, J Voglmeir, S Flitsch
Cracking the Sugar Code by Navigating the Glycospace, 93-105

Formation of carbohydrate-functionalised polystyrene and glass slides and their analysis by MALDI-TOF MS   , Martin J Weissenborn, Johannes W Wehner, Christopher J Gray, Robert  Šardzík, Claire E Eyers, Thisbe K Lindhorst, Sabine L Flitsch
Beilstein Journal of Organic Chemistry 8 (1), 753-762

Chemoenzymatic Synthesis of O-Mannosylpeptides in Solution and on Solid Phase   , Robert Sardzik, Anthony P Green, Nicolas Laurent, Peter Both, Carolina  Fontana, Josef Voglmeir, Martin J Weissenborn, Rose Haddoub, Paola  Grassi, Stuart M Haslam, Goran Widmalm, Sabine L Flitsch
Journal of the American Chemical Society 134 (10), 4521-4524

Dual purpose S-trityl-linkers for glycoarray fabrication on both polystyrene and gold   , Johannes W Wehner, Martin J Weissenborn, Mirja Hartmann, Christopher J  Gray, Robert Šardzík, Claire E Eyers, Sabine L Flitsch, Thisbe K  Lindhorst
Organic & biomolecular chemistry 10 (44), 8919-8926

Oxo-ester mediated native chemical ligation on microarrays: an efficient and chemoselective coupling methodology   , Martin J Weissenborn, Roberto Castangia, Johannes W Wehner, Robert Šardzík, Thisbe K Lindhorst, Sabine L Flitsch
Chemical Communications 48 (37), 4444-4446

2010

Enzymatic glycosylations on arrays   , J Voglmeir, R Šardzík, MJ Weissenborn, SL Flitsch
Omics: a journal of integrative biology 14 (4), 437-444

Preparation of aminoethyl glycosides for glycoconjugation   , R Šardzík, GT Noble, MJ Weissenborn, A Martin, SJ Webb, SL Flitsch
Beilstein journal of organic chemistry 6 (1), 699-703

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