Martin-Luther-Universität Halle-Wittenberg


TP2_Binder.pdf (880,8 KB)  vom 15.04.2010


Prof. Dr. Wolfgang Binder

Telefon: 0345 5525930
Telefax: 0345 5527392

Raum 4.09.0
von-Danckelmann-Platz 4
06129 Halle

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Martin-Luther-Universität Halle-Wittenberg
Naturwissenschaftliche Fakultät II
Institut für Chemie
Makromolekulare Chemie
von-Danckelmann-Platz 4
06120 Halle (Saale)


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Self-assembly of nanoparticles at the interface of lipid- and polymersomal membranes

Membranes can be fabricated either from lipid or polymer molecules, leading to the formation of liposomes or polymersomes. In all types of liposomal membranes the issue of phase separation plays a central role not only in the membrane-formation, but also in the resulting structural features taking place within or at the surface of such membranes. Thus features of lateral phase separation can take part between the inner/outer parts of a polymersome or via the formation of distortions by selective swelling of a specific polymeric phase. When nanoparticles or polymers interact with lipid membranes, the final morphology is strongly determined by the charge, composition and size of the interacting components. The present project investigates the self-assembly processes of nanoparticles at lipid/polymer interfaces in mono- as well as bilayer membranes. Both, the synthesis of designed amphiphilic polymers and the preparation of CdSe-nanoparticles displaying various surfaces, coated with polymers, are investigated. This finally enables the selective location of nanoparticles in mixed membranes, composed of lipid- and polymer molecules.

TP 2 Figure 1

TP 2 Figure 1

TP 2 Figure 1

References :

[1]        M. Schulz, A. Olubummo, and W. H. Binder, “Beyond the Lipid-Bilayer: Interaction of Polymers and Nanoparticles with Membranes,” Soft Matter, vol. 8, no. 18, pp. 4849–4864, 2012.

[2]        M. Schulz, D. Glatte, A. Meister et al., “Hybrid lipid/polymer giant unilamellar vesicles: effects of incorporated biocompatible PIB-PEO block copolymers on vesicle properties,” Soft Matter, vol. 7, no. 18, pp. 8100-8110, 2011.

[3]        N. Li, and W. H. Binder, “Click-Chemistry for Nanoparticle-Modification,” J. Mater. Chem. , vol. 21, no. 42, pp. 16717 - 16734, 2011.

[4]        H. Li, R. Sachsenhofer, W. H. Binder et al., “Hierarchical Organization of Poly(ethylene oxide)-block-poly(isobutylene) and Hydrophobically Modified Fe2O3 Nanoparticles at the Air/Water Interface and on Solid Supports,” Langmuir, vol. 25, no. 14, pp. 8320-8329, 2009.

[5]        H. Li, D. Pfefferkorn, W. H. Binder et al., “Phospholipid Langmuir Film as Template for in Situ Silica Nanoparticle Formation at the Air/Water Interface,” Langmuir, vol. 25, no. 23, pp. 13328-13331, 2009.

[6]        W. H. Binder, and R. Sachsenhofer, “Polymersome/Silica Capsules by "Click"-Chemistry,” Macromol. Rapid Commun., vol. 29, no. 12-13, pp. 1097-1103, 2008.

[7]        W. H. Binder, R. Sachsenhofer, D. Farnik et al., “Guiding the location of nanoparticles into vesicular structures: a morphological study,” Phys. Chem. Chem. Phys., vol. 9, no. 48, pp. 6435-6441, 2007.

[8]        A. Haryono, and W. H. Binder, “Controlled Arrangement of Nanoparticle Arrays in Block-Copolymer Domains,” Small, vol. 2, no. 5, pp. 600-611, 2006.

[9]        W. H. Binder, C. Kluger, M. Josipovic et al., “Directing Supramolecular Nanoparticle Binding onto Polymer Films: Film Formation and Influence of Receptor Density on Binding Densities,” Macromolecules, vol. 39, no. 23, pp. 8092-8101, 2006.

[10]      R. Zirbs, F. Kienberger, P. Hinterdorfer et al., “Directed Assembly of Au Nanoparticles onto Planar Surfaces via Multiple Hydrogen Bonds,” Langmuir, vol. 21, no. 18, pp. 8414-8421, 2005.

[11]      W. H. Binder, “Supramolecular Assembly of Nanoparticles at Liquid-Liquid Interfaces,” Angew. Chem., Int. Ed. , vol. 44, no. 33, pp. 5172-5175, 2005.

[12]      W. H. Binder, V. Barragan, and F. M. Menger, “Domains and Rafts in Lipid Membranes,” Angew. Chem., Int. Ed. , vol. 42, no. 47, pp. 5802-5827, 2003.

[13]     W. H. Binder, “Polymer-Induced Transient Pores in Lipid Membranes,” Angew. Chem. Int. Ed., vol. 47, no. 17, pp. 3092-3095, 2008.

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