Martin-Luther-Universität Halle-Wittenberg


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Interaction of synthetic antimicrobial and charged model peptides with lipid monolayers and lipid vesicles

  • Binding of antimicrobial peptides to lipid monolayers studied by infrared reflection absorption spectroscopy (IRRAS).
  • Binding of antimicrobial peptides to lipid vesicles studied by differential scanning calorimetry (DSC) and isothermal titration calorimetry (ITC).
  • ATR-IR-spectroscopy on binding of peptides to solid supported membranes.
  • Permeabilization of lipid vesicles by peptides studied with fluorescence spectroscopy

Interaction of detergents with lipid vesicles

  • Mechanism of the transformation of lipid vesicles to mixed micelles
  • Influence of the chemical structure of detergents and the bilayer properties on the vesicle-micelle transition.
  • Thermodynamics of the interaction of detergents with lipid vesicles studied by differential scanning calorimetry (DSC) and isothermal titration calorimetry (ITC).
  • Determination of mixed micelle structure by dynamic light scattering (DLS), small angle neutron scattering (SANS) and transmission electron microscopy (TEM)
  • The kinetics of detergent incorporation into lipid membranes and kinetics of detergent flip-flop studied by stopped-flow techniques with light-scattering and fluorescence detection (quenching and fluorescence resonance energy transfer, FRET)

Self-assembly of single-chain bolaamphiphiles in water

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  • Structure-property relationship in stimulus-responsive hydrogels formed by bolaamphiphile nanofibers
  • Rheological properties of bolaamphiphile hydrogels
  • Fixation of AuNPs to nanofibers
  • Influence of headgroup size and spacer composition on the self-assembly process
  • Mixing behaviour of bolaamphiphiles of different length
  • Mixing behaviour of bolaamphiphiles with phospholipids
  • Conformational analysis of bolaamphiphiles at the air-water interface
  • Bolaamphiphile nanofibers with polymerizable groups
  • Dynamics of nanofiber formation

Insertion of Subunits of the TAT Protein Complex into Artificial Membrane Systems (go to web site)

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  • Functional insertion of the TAT subunits into artificial membrane systems like lipid vesicles and planar monolayer/bilayer systems.
  • Biophysical characterization of thylakoid and bacterial membrane model systems.
  • Interaction of TAT protein substrates (i.e. EGFP as a model substrate for the thylakoidal system) and signalling peptides with model monolayers investigated using FT-IR reflection absorption spectroscopy (FT-IRRAS) at the air/water interface

Influence of alimental ingredients on the kinetics of de- and remineralization of human enamel (Bob-Dan Lechner)

  • Topological investigation of enamel and dentine erosion by acidic food stuffs in vitro with atomic force microscopy (AFM), infrared spectroscopy and microscopy (ATR-FTIR, FTIR-Mic.), and electron microscopy (REM, ESEM).
  • Kinetic and structural investigations on remineralization of enamel and dentine by artificial agents and food with nanotomography.
  • Characterization of remineralized material with infrared spectroscopy (ATR-FTIR), energy-dispersive X-ray spectroscopy (EDX) and X-ray powder diffraction (XRD).
  • Impact of saliva and calcium ion containing additives in food on the erosion and remineralization of dental hard tissue.
  • Photo-documentary in vivo studies with dental patients on enamel erosion and remineralization by food and pathogenic factors.

Structure-property relationship in the functional complex of the neuronal membrane protein guanylate cyclase from photoreceptor membranes

Interaction of polyphilic block-copolymers with lipid monolayers and bilayers

Lyotropic behaviour of amphiphilic and polyphilic molecules with low molecular weight and their interaction and structure fomation tendencies with lipid monolayers and bilayers

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